Results 121 to 130 of about 5,114,170 (301)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

On Construction of Solutions of Hyperbolic Kirchhoff-Type Problems Involving Free Boundary and Volume Constraint

open access: yesMathematics
In this paper, we have undertaken the challenging and novel task of establishing the existence of weak solutions for four types of hyperbolic Kirchhoff-type problems: the classical hyperbolic Kirchhoff problem, the problem with a free boundary, the ...
Fatima Ezahra Bentata   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

Weak Solution and Weakly Uniformly Bounded Solution of Impulsive Heat Equations Containing “Maximum” Temperature

open access: yes, 2013
In this paper, criteria for the existence of weak solutions and uniformly weak bounded solution of impulsive heat equation containing maximum temperature are investigated and results obtained.
Oyelami, Benjamin Oyediran
core  

A new old solution for weak tournaments [PDF]

open access: yes, 2010
This note uncovers new properties of the von Neumann-Morgenstern solution in weak tournaments and majoritarian games. We propose a new procedure for the construction of choice sets from weak tournaments, based on dynamic stability criteria.
Anesi, Vincent
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

What's the Use? Welfare Estimates from Revealed Preference Models when Weak Complementarity Does Not Hold [PDF]

open access: yes
In this paper we consider the theoretical and empirical ramifications of welfare measurement in revealed preference models when weak complementarity does not hold.
Kling, Catherine L.   +2 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Unilateral problems for the Klein-Gordon operator with nonlinearity of Kirchhoff-Carrier type

open access: yesElectronic Journal of Differential Equations, 2015
This work concerns the unilateral problem for the Klein-Gordon operator $$ \mathbb{L}=\frac{\partial^2 u}{\partial t^2}-M(|\nabla u|^2)\Delta u+M_1(|u|^2)u-f.
Carlos Raposo   +3 more
doaj  

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