Results 131 to 140 of about 696,986 (308)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Global regularity and uniqueness of weak solution for the 2-D liquid crystal flows

open access: yes, 2012
We prove the global existence and regularity of weak solution for the 2-D liquid crystal flows with the large initial velocity.
Zhang, Zhifei   +3 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

A discontinuous nonlinear singular elliptic problem with the fractional rho-Laplacian

open access: yesNonlinear Analysis
In this paper, we use the topological degree method, based on the abstract Hammerstein equation, to investigate the existence of weak solutions for a certain class of elliptic Dirichlet boundary value problems.
Ghizlane Zineddaine   +3 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Weak solution to the Navier-Stokes equations

open access: yes
We derive the weak formulation of the Navier-Stokes equations directly from the basic physical principles, showing that the weak formulation and thus also the weak solution are completely natural for this system.
Šegeda, Adrián
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

CONDORCET CHOICE FUNCTIONS AND MAXIMAL ELEMENTS [PDF]

open access: yes
Choice functions on tournaments always select the maximal element (Condorcet winner), provided they exist, but this property does not hold in the more general case of weak tournaments.
Begoña Subiza Martínez   +1 more
core  

Weak solution for Stochastic Degasperis-Procesi Equation

open access: yes
This article is concerned with the existence of solution to the stochastic Degasperis-Procesi equation on $\mathbb{R}$ with an infinite dimensional multiplicative noise and integrable initial data.
Chemetov, Nikolai V., Cipriano, Fernanda
core   +1 more source

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