Results 111 to 120 of about 634,419 (341)

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

open access: yesFEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He   +5 more
wiley   +1 more source

2D Stochastic Chemotaxis-Navier-Stokes System [PDF]

open access: yesarXiv, 2017
In this paper, we establish the existence and uniqueness of both mild(/variational) solutions and weak (in the sense of PDE) solutions of coupled system of 2D stochastic Chemotaxis-Navier-Stokes equations. The mild/variational solution is obtained through a fixed point argument in a purposely constructed Banach space.
arxiv  

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

On viscosity and weak solutions for non-homogeneous p-Laplace equations

open access: yesAdvances in Nonlinear Analysis, 2017
In this manuscript, we study the relation between viscosity and weak solutions for non-homogeneous p-Laplace equations with lower-order term depending on x, u and ∇⁡u{\nabla u}.
Medina Maria, Ochoa Pablo
doaj   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

open access: yesFEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda   +15 more
wiley   +1 more source

Weak Random Periodic Solutions of Random Dynamical Systems [PDF]

open access: yesarXiv, 2019
We first introduce the concept of weak random periodic solutions of random dynamical systems. Then, we discuss the existence of such periodic solutions. Further, we introduce the definition of weak random periodic measures and study their relationship with weak random periodic solutions.
arxiv  

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

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