Results 121 to 130 of about 3,919,417 (298)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Regularity of weak solutions to the Landau-Lifshitz system in bounded regular domains

open access: yesElectronic Journal of Differential Equations, 2007
In this paper, we study the regularity, on the boundary, of weak solutions to the Landau-Lifshitz system in the framework of the micromagnetic model in the quasi-static approximation.
Kevin Santugini-Repiquet
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

On a sublinear nonlocal fractional problem

open access: yesNonlinear Analysis
This paper deals with existence results of nonnegative solutions for a one-parameter sublinear elliptic boundary-value problem driven by the classical fractional Laplacian operator.
Giovanni Molica Bisci   +1 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Generalized quasi-linear fractional Wentzell problems

open access: yesAdvances in Nonlinear Analysis
Given a bounded (ε,δ)\left(\varepsilon ,\delta )-domain Ω⊆RN\Omega \subseteq {{\mathbb{R}}}^{N} (N≥2N\ge 2) whose boundary Γ≔∂Ω\Gamma := \partial \Omega is a dd-set for d∈(N−p,N)d\in \left(N-p,N), we investigate a generalized quasi-linear elliptic ...
Mesino-Espinosa Efren   +1 more
doaj   +1 more source

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