Results 121 to 130 of about 1,716,851 (287)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

Existence of solutions for quasilinear elliptic degenerate systems with L^1 data and nonlinearity in the gradient

open access: yesElectronic Journal of Differential Equations, 2013
In this article we show the existence of weak solutions for some quasilinear degenerate elliptic systems arising in modeling chemotaxis and angiogenesis.
Abdelhaq Mouida   +3 more
doaj  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Generalized quasi-linear fractional Wentzell problems

open access: yesAdvances in Nonlinear Analysis
Given a bounded (ε,δ)\left(\varepsilon ,\delta )-domain Ω⊆RN\Omega \subseteq {{\mathbb{R}}}^{N} (N≥2N\ge 2) whose boundary Γ≔∂Ω\Gamma := \partial \Omega is a dd-set for d∈(N−p,N)d\in \left(N-p,N), we investigate a generalized quasi-linear elliptic ...
Mesino-Espinosa Efren   +1 more
doaj   +1 more source

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