Results 51 to 60 of about 634,419 (341)

Qualitative Analysis of a Control-Volume Fibre Coating Model

open access: yesJournal of Optimization, Differential Equations and Their Applications
This paper presents qualitative analysis of the solutions to a control-volume model for liquid films flowing down a vertical fibre. Time evolution of the free surface is governed by a coupled system of degenerate nonlinear partial differential equations,
R. M. Taranets, M. Chugunova
doaj   +1 more source

Global weak solutions for a two-component Novikov system [PDF]

open access: yesarXiv, 2020
In this paper, we mainly consider about the existence and uniqueness of global weak solutions for the two-component Novikov system. We first recall some results and definitions of strong solutions and weak solutions for the system, then by using the method of approximation of smooth solutions, we prove the existence and uniqueness of global weak ...
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Global Weak Solutions for the Half-Wave Maps Equation in $\mathbb{R}$ [PDF]

open access: yesarXiv, 2023
We establish the existence of weak global solutions of the half-wave maps equation with the target $S^2$ on $\mathbb{R}^{1+1}$ with large initial data in $\dot{H}^1 \cap \dot{H}^{\frac{1}{2}}(\mathbb{R})$. We first prove the global well-posedness of a regularized equation. Then we show that the weak limit of the regularized solutions is a weak solution
arxiv  

Sequences of weak solutions for fractional equations [PDF]

open access: yesMathematical Research Letters, 2014
This work is devoted to study the existence of infinitely many weak solutions to nonlocal equations involving a general integrodifferential operator of fractional type. These equations have a variational structure and we find a sequence of nontrivial weak solutions for them exploiting the ${\mathbb{Z}}_2$-symmetric version of the Mountain Pass Theorem.
openaire   +4 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Q fever outbreak in the terraced vineyards of Lavaux, Switzerland

open access: yesNew Microbes and New Infections, EarlyView., 2014
Abstract Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux ...
C. Bellini   +9 more
wiley   +1 more source

Global compact attractors and complete bounded trajectories for compressible magnetohydrodynamic system of equations [PDF]

open access: yesTheoretical and Applied Mechanics
In this article, we investigate the global behavior of magnetohydrodynamic (MHD) fluid’s weak solutions in three-dimensional bounded domain with a compact Lipschitz boundary driven by arbitrary forces.
Muhammad Jan
doaj   +1 more source

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