Results 71 to 80 of about 4,087,279 (255)
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
On asymptotic behavior of global solutions for hyperbolic hemivariational inequalities
Electronic Journal of Differential Equations, 2006 In this paper we study the existence of global weak solutions for a hyperbolic differential inclusion with a discontinuous and nonlinear multi-valued term. Also we investigate the asymptotic behavior of solutions.
Jong Yeoul Park, Sun Hye Park
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On the Volterra integral equation and axiomatic measures of weak noncompactness [PDF]
, 2001 summary:We prove that a set of weak solutions of the nonlinear Volterra integral equation has the Kneser property.
Bugajewski, Dariusz
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Weak solutions for parabolic equations with p(x)-growth
Electronic Journal of Differential Equations, 2016 In this article we study nonlinear parabolic equations with p(x)-growth in the space $W^{1,x}L^{p(x)}(Q)\cap L^\infty(0,T; L^2(\Omega))$. By using the method of parabolic regularization, we prove the existence and uniqueness of weak solutions for the
Ning Pan, Binlin Zhang, Jun Cao
doaj
On a class of superlinear nonlocal fractional problems without Ambrosetti–Rabinowitz type conditions
Electronic Journal of Qualitative Theory of Differential Equations, 2019 In this note, we deal with the existence of infinitely many solutions for a problem driven by nonlocal integro-differential operators with homogeneous Dirichlet boundary conditions \begin{equation*} \begin{cases} -\mathcal{L}_{K}u=\lambda f(x,u), &
Qing-Mei Zhou
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