Results 81 to 90 of about 4,087,279 (255)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2021 Weak solutions, of variational inequality type, are introduced. Their defining properties can be equivalently expressed in terms of quadrature identities for subharmonic functions, or in terms of partial balayage.
Lin, Yu-Lin, +3 more
core +1 more source
Weak solutions for a viscous p-Laplacian equation
Electronic Journal of Differential Equations, 2003 In this paper, we consider the pseudo-parabolic equation $ u_t-kDelta u_t=mathop{ m div}(| abla u|^{p-2} abla u)$. By using the time-discrete method, we establish the existence of weak solutions, and also discuss the uniqueness.
Changchun Liu
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
AxiomsA system of nonlinear wave equations in viscoelasticity with variable exponents is considered. It is assumed that the kernel included in the integral term of the equations depends on both the time and the spatial variables.
Mouhssin Bayoud +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the stationary Cahn-Hilliard equation: Interior spike solutions [PDF]
, 1998 We study solutions of the stationary Cahn-Hilliard equation in a bounded smooth domain which have a spike in the interior. We show that a large class of interior points (the "nondegenerate peak" points) have the following property: there exist such ...
Winter, M, Wei, J
core +1 more source
The Poisson equation from non-local to local
Electronic Journal of Differential Equations, 2018 We analyze the limiting behavior as $s\to 1^-$ of the solution to the fractional Poisson equation $(-\Delta)^s{u_s}=f_s$, $x\in\Omega$ with homogeneous Dirichlet boundary conditions $u_s\equiv 0$, $x\in\Omega^c$. We show that $\lim_{s\to 1^-} u_s =u$,
Umberto Biccari +1 more
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source