Results 51 to 60 of about 4,087,279 (255)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
On Pacard's regularity for the equation $-Delta u = u^p$
Electronic Journal of Differential Equations, 2012 It is shown that the singular set for a positive solution of the PDE $-Delta u = u^p$ has Hausdorff dimension less than or equal to $n - 2p'$, as conjectured by Pacard [12 in 1993.
David R. Adams
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Global compact attractors and complete bounded trajectories for compressible magnetohydrodynamic system of equations [PDF]
Theoretical and Applied MechanicsIn this article, we investigate the global behavior of magnetohydrodynamic (MHD) fluid’s weak solutions in three-dimensional bounded domain with a compact Lipschitz boundary driven by arbitrary forces.
Muhammad Jan
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Renormalized solutions of the 2D Euler equations [PDF]
, 2015 In this paper we prove that solutions of the 2D Euler equations in vorticity formulation obtained via vanishing viscosity approximation are ...
Spirito, Stefano, Crippa, Gianluca
core +1 more source
On a nonlinear degenerate evolution equation with strong damping
International Journal of Mathematics and Mathematical Sciences, 1992 In this paper we consider the nonlinear degenerate evolution equation with strong damping,(*) {K(x,t)utt−Δu−Δut+F(u)=0 in Q=Ω×]0,T[u(x,0)=u0, (ku′)(x,0)=0 in Ωu(x,t)=0 on ∑=Γ×]0,T[where K is a function with K(x,t)≥0, K(x,0)=0 ...
Jorge Ferreira +1 more
doaj +1 more source
Journal of Optimization, Differential Equations and Their Applications, 2018 We study here Dirichlet boundary value problem for a quasi-linear elliptic equation with anisotropic p-Laplace operator in its principle part and L^1-control in coefficient of the low-order term.
Peter I. Kogut, Olha P. Kupenko
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source