Results 71 to 80 of about 1,691,019 (337)

Weak-strong uniqueness of hydrodynamic flow of nematic liquid crystals

Electronic Journal of Differential Equations, 2012
This article concerns a simplified model for a hydrodynamic system of incompressible nematic liquid crystal materials. It is shown that the weak-strong uniqueness holds for the class of weak solutions provided that either $(mathbf{u}, ablamathbf{d ...
Ji-hong Zhao, Qiao Liu
doaj  

SYMMETRY GROUP ANALYSIS OF WEAK SOLUTIONS [PDF]

Proceedings of the London Mathematical Society, 2002
Methods of Lie group analysis of differential equations are extended to weak solutions of (linear and non-linear) partial differential equations, where the term `weak solution' comprises the following settings: distributional solutions; solutions in generalized function algebras; solutions in the sense of association (corresponding to a number of weak ...
Dapic, N, Kunzinger, Michael, Pilipovic, Stevan   +2 more
openaire   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Weak solutions for a strongly-coupled nonlinear system

Electronic Journal of Differential Equations, 2006
In this paper the authors study the existence of local weak solutions of the strongly nonlinear system $$displaylines{ u''+mathcal{A}u +f(u,v)u = h_1 cr v''+mathcal{A}v +g(u,v)v = h_2 }$$ where $mathcal{A}$ is the pseudo-Laplacian operator and $f$, $g$, $
Osmundo A. Lima, Aldo T. Louredo, Alexandro O. Marinho   +2 more
doaj  

On a class of superlinear nonlocal fractional problems without Ambrosetti–Rabinowitz type conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2019
In this note, we deal with the existence of infinitely many solutions for a problem driven by nonlocal integro-differential operators with homogeneous Dirichlet boundary conditions \begin{equation*} \begin{cases} -\mathcal{L}_{K}u=\lambda f(x,u), &
Qing-Mei Zhou
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Parabolic Harnack inequality for time-dependent non-symmetric Dirichlet forms [PDF]

, 2016
In the context of a metric measure Dirichlet space satisfying volume doubling and Poincar\'e inequality, we prove the parabolic Harnack inequality for weak solutions of the heat equation associated with local nonsymmetric bilinear forms.
Lierl, Janna, Saloff-Coste, Laurent
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