Results 71 to 80 of about 1,716,851 (287)

On a class of superlinear nonlocal fractional problems without Ambrosetti–Rabinowitz type conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2019
In this note, we deal with the existence of infinitely many solutions for a problem driven by nonlocal integro-differential operators with homogeneous Dirichlet boundary conditions \begin{equation*} \begin{cases} -\mathcal{L}_{K}u=\lambda f(x,u), &
Qing-Mei Zhou
doaj   +1 more source

Parabolic Harnack inequality for time-dependent non-symmetric Dirichlet forms [PDF]

, 2016
In the context of a metric measure Dirichlet space satisfying volume doubling and Poincar\'e inequality, we prove the parabolic Harnack inequality for weak solutions of the heat equation associated with local nonsymmetric bilinear forms.
Lierl, Janna, Saloff-Coste, Laurent
core  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

On asymptotic behavior of global solutions for hyperbolic hemivariational inequalities

Electronic Journal of Differential Equations, 2006
In this paper we study the existence of global weak solutions for a hyperbolic differential inclusion with a discontinuous and nonlinear multi-valued term. Also we investigate the asymptotic behavior of solutions.
Jong Yeoul Park, Sun Hye Park
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Weak solutions for a strongly-coupled nonlinear system

Electronic Journal of Differential Equations, 2006
In this paper the authors study the existence of local weak solutions of the strongly nonlinear system $$displaylines{ u''+mathcal{A}u +f(u,v)u = h_1 cr v''+mathcal{A}v +g(u,v)v = h_2 }$$ where $mathcal{A}$ is the pseudo-Laplacian operator and $f$, $g$, $
Osmundo A. Lima, Aldo T. Louredo, Alexandro O. Marinho   +2 more
doaj  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Global compact attractors and complete bounded trajectories for compressible magnetohydrodynamic system of equations [PDF]

Theoretical and Applied Mechanics
In this article, we investigate the global behavior of magnetohydrodynamic (MHD) fluid’s weak solutions in three-dimensional bounded domain with a compact Lipschitz boundary driven by arbitrary forces.
Muhammad Jan
doaj   +1 more source