Results 81 to 90 of about 1,716,851 (287)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The Poisson equation from non-local to local
Electronic Journal of Differential Equations, 2018 We analyze the limiting behavior as $s\to 1^-$ of the solution to the fractional Poisson equation $(-\Delta)^s{u_s}=f_s$, $x\in\Omega$ with homogeneous Dirichlet boundary conditions $u_s\equiv 0$, $x\in\Omega^c$. We show that $\lim_{s\to 1^-} u_s =u$,
Umberto Biccari +1 more
doaj
Determining Projections and Functionals for Weak Solutions of the Navier-Stokes Equations
, 2010 In this paper we prove that an operator which projects weak solutions of the two- or three-dimensional Navier-Stokes equations onto a finite-dimensional space is determining if it annihilates the difference of two "nearby" weak solutions asymptotically ...
Holst, Michael, Titi, Edriss
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
THE COMPRESSIBLE MICROPOLAR FLUIDS MODEL: RELATIVE ENTROPIES, SUITABLE WEAK SOLUTIONS AND WEAK-STRONG UNIQUENESS [PDF]
, 2022 Jingrui Su
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The Nonlocal Porous Medium Equation: Barenblatt Profiles and Other Weak Solutions [PDF]
, 2014 Piotr Biler +2 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Regularity for solutions to the Navier-Stokes equations with one velocity component regular
Electronic Journal of Differential Equations, 2002 In this paper, we establish a regularity criterion for solutions to the Navier-stokes equations, which is only related to one component of the velocity field. Let $(u, p)$ be a weak solution to the Navier-Stokes equations.
Cheng He
doaj