Results 51 to 60 of about 31,762 (259)
SensorsHuman activity recognition (HAR) using wearable sensors has advanced through various machine learning paradigms, each with inherent trade-offs between performance and labeling requirements.
Taoran Sheng, Manfred Huber
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Weakly- and Semi-supervised Panoptic Segmentation [PDF]
, 2018 ECCV 2018.
Qizhu Li +2 more
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Weakly Supervised PLDA Training
CoRR, 2016 PLDA is a popular normalization approach for the i-vector model, and it has delivered state-of-the-art performance in speaker verification. However, PLDA training requires a large amount of labelled development data, which is highly expensive in most cases.
Lantian Li +3 more
openaire +2 more sources
A Convex Relaxation for Weakly Supervised Classifiers [PDF]
Proceedings of the International Conference on Machine Learning (ICML), 2012 This paper introduces a general multi-class approach to weakly supervised classification. Inferring the labels and learning the parameters of the model is usually done jointly through a block-coordinate descent algorithm such as expectation-maximization (EM), which may lead to local minima.
Joulin, Armand, Bach, Francis
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Weakly Supervised Captioning of Ultrasound Images
, 2022 Medical image captioning models generate text to describe the semantic contents of an image, aiding the non-experts in understanding and interpretation. We propose a weakly-supervised approach to improve the performance of image captioning models on small image-text datasets by leveraging a large anatomically-labelled image classification dataset.
Mohammad Alsharid +4 more
openaire +3 more sources