Results 71 to 80 of about 31,762 (259)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Weakly-Supervised Evidence Pinpointing and Description [PDF]

, 2017
We propose a learning method to identify which specific regions and features of images contribute to a certain classification. In the medical imaging context, they can be the evidence regions where the abnormalities are most likely to appear, and the discriminative features of these regions supporting the pathology classification.
Qiang Zhang 0009, Abhir Bhalerao, Charles Hutchinson   +2 more
openaire   +1 more source

A Weakly Supervised and Self-Supervised Learning Approach for Semantic Segmentation of Land Cover in Satellite Images with National Forest Inventory Data

Remote Sensing
National Forest Inventories (NFIs) provide valuable land cover (LC) information but often lack spatial continuity and an adequate update frequency. Satellite-based remote sensing offers a viable alternative, employing machine learning to extract thematic
Daniel Moraes, Manuel L. Campagnolo, Mário Caetano   +2 more
doaj   +1 more source

Learning Neural Sequence-to-Sequence Models from Weak Feedback with Bipolar Ramp Loss

Transactions of the Association for Computational Linguistics, 2019
In many machine learning scenarios, supervision by gold labels is not available and conse quently neural models cannot be trained directly by maximum likelihood estimation.
Jehl, Laura, Lawrence, Carolin, Riezler, Stefan   +2 more
doaj   +1 more source

PistonNet: Object Separating From Background by Attention for Weakly Supervised Ship Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2022
Object detection under weakly supervised learning is a challenging issue. In a remote sensing ship detection task, the weakly supervised learning method requires that the training set only has image-level class annotations.
Yi Yang, Zongxu Pan, Yuxin Hu, Chibiao Ding   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

WSF-NET: Weakly Supervised Feature-Fusion Network for Binary Segmentation in Remote Sensing Image

Remote Sensing, 2018
Binary segmentation in remote sensing aims to obtain binary prediction mask classifying each pixel in the given image. Deep learning methods have shown outstanding performance in this task.
Kun Fu, Wanxuan Lu, Wenhui Diao, Menglong Yan, Hao Sun, Yi Zhang, Xian Sun   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source