Results 81 to 90 of about 458,996 (249)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Journal of Veterinary Internal MedicineBackground Major genetic risk loci and causative mutations classified as LPN1 (Leonberger polyneuropathy type 1), LPN2 (Leonberger polyneuropathy type 2), and LPPN3 (Laryngeal paralysis polyneuropathy type 3) have been identified in Leonberger and Saint ...
G. Diane Shelton +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Health Science ReportsBackground and Aims The COVID‐19 pandemic has changed the traditional models of providing services in health systems. One of the recommended ways to provide healthcare services in this era is teleconsultation. This study aimed to determine the strengths,
Shiva Khoshsirat +2 more
doaj +1 more source
Asymmetric threat to the security of the Republic of Serbia: Theoretical framework for the analysis of problems in Kosovo and Metohia [PDF]
Politika nacionalne bezbednostiThe application of the concept of asymmetry in the domain of security enables a comprehensive overview of the strategic relations between the opposing parties, as well as the methods used by the adversaries in an effort to turn this type of inequality ...
Barišić Igor
doaj +1 more source
Journal of Algebra, 2001 Let \(A\) be an associative algebra with unit. The author introduces the concept of a weak \(A\)-coring, where the left and the right structure of module of the coring need not to be unital. The theory of weak corings is related with the weak entwined structures introduced by \textit{S. Caenepeel} and \textit{E. de Groot} [Contemp. Math.
openaire +2 more sources
Weak Scale Supersymmetry without Weak Scale Supergravity [PDF]
Physical Review Letters, 2002 9 pages, LaTeX2e, no ...
openaire +3 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Physical Review D, 1996 harvmac, 14 pages. References added, 3 typos fixed, Comments added at beginning of section 4 emphasizing flaws of the toy ...
openaire +3 more sources