Results 141 to 150 of about 1,403,195 (294)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Foundations of PhysicsAbstract Weak values characterize a quantum system in the period of time between preparation and measurement and may lie outside the eigenvalue spectrum of the measured operator. The probability of such “superweak" values for random quantum states has been calculated and applied to Klein–Gordon and Dirac waves, where the maximal probability ...
openaire +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
The relationship marketing in the process of customer loyalty. Case large construction of Manizales
Inquietud Empresarial, 2015 This paper is based on the model Lindgreen (2001), upholding the relationship marketing should be approached in three dimensions: objectives, definition of constructs and tools, which enable better customer management within organizations.
María Cristina Torres Camacho +1 more
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Economic Development Potential Of The Krakow Region [PDF]
, 2007 Analyzing economic development potential and activities in a region requires identifying factors essential for a successful strategy and analyzing the locale in terms of its resources and relative position within a broader economic environment.
Boryczko, Alicja
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
On Organizational Configurations [PDF]
, 2012 [Excerpt] To manage organizations in ways that will make our society manageable, we need to spark innovations in management. Consider the organization in which you work. What configuration does it have and what does that tell you?
Serrat, Olivier
core +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
A note on the Trolley Problem and Three Weaknesses of Economic Theory [PDF]
The trolley problem is a moral dilemmas in which human lives are in danger and some, but not all, can be saved by direct intervention of a decision-maker. This article discusses three weaknesses of microeconomics with respect to individual conduct in the
Alessandro Lanteri
core