Results 71 to 80 of about 1,403,195 (294)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

BOOK REVIEW OF THE HAPPINESS PROJECT WRITTEN BY GRETCHEN RUBIN [PDF]

open access: yes, 2016
This book review analyzes the strengths and weaknesses of Gretchen Rubin’s The Happiness Project. The Happiness Project is a novel about how to pursuit happiness in life.
Prasetyo, Mochammad Afrizal
core   +1 more source

Weak comonotonicity

open access: yesEuropean Journal of Operational Research, 2018
The classical notion of comonotonicity has played a pivotal role when solving diverse problems in economics, finance, and insurance. In various practical problems, however, this notion of extreme positive dependence structure is overly restrictive and sometimes unrealistic.
Ruodu Wang, Ričardas Zitikis
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Diagnóstico de las micro, pequeñas y medianas empresas en distritos de Orotina, Montes de Oro, El Roble, Barranca, Chacarita, Puntarenas, Esparza y Jacó

open access: yesRevista de Ciencias Economicas, 2011
El presente trabajo muestra una serie de variables e indicadores empresariales que ofrecen un panorama general de las micro, pequeñas y medianas empresas (mipymes) de varios distritos y cantones de la región Pacífico Central: Puntarenas, Barranca ...
Susan Chen Mok, Kathia García Cousin
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Strengths and weaknesses of European integration for the Republic of Serbia [PDF]

open access: yesTrendovi u Poslovanju
European integration represents the process through which European states are connected through legal, social, political, industrial, economic, and cultural associations. This is achievable with the help of the European Union and its regulations.
Đurović Mihajlo   +2 more
doaj   +1 more source

Introduction and criticism of the book Homelessness and Social Policy [PDF]

open access: yesمسائل اجتماعی ایران, 2023
The book Homelessness and Social Policy is written by Rogers Burroughs, Nicholas Place and Deborah Quilgars; which was translated by Mohammad Khani; And it has been published in 2017 by the Scientific and Cultural Publishing House at the request of the ...
Javad Maddahi   +2 more
doaj  

Justifying Justice: Six Factors of Wrongful Convictions and Their Solutions [PDF]

open access: yes, 2019
There have been over 300 post-conviction DNA exonerations in the history of the United States. While this number may initially seem significant, there is still an unfathomable population of wrongfully convicted prisoners who have yet to be considered for
Duncan, Colby
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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