Results 21 to 30 of about 125,677 (264)

Olfactory enrichment using a maternal pheromone improved post-weaning pig performance and behavior

Frontiers in Veterinary Science, 2022
The post-weaning environment in commercial pig nursery buildings is typically devoid of both the sow and her semiochemicals. Among other factors, the loss of maternal odors may contribute to post-weaning stress.
Courtney Archer, Arlene Garcia, Madelyn Henderson, John J. McGlone   +3 more
doaj   +1 more source

Effects of Donepezil and Medroxyprogesterone Versus Placebo on Weaning in Adult Patients With Non-Pulmonary Etiologies Receiving Invasive Mechanical Ventilation: A triple‐blind Randomized Clinical Trial

Frontiers in Pharmacology, 2021
Background: Medroxyprogesterone and donepezil could be used as respiratory stimulants in ventilated patients. However, no randomized placebo-controlled trial is available to confirm this approach and compare these drugs.
Zahra Alizadeh, Adeleh Sahebnasagh, Navid Hadadzadegan, Farhad Mohammadi, Fatemeh Saghafi   +4 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Associations between Features of External Ventricular Drain Management, Disposition, and Shunt Dependence

Journal of Neuroanaesthesiology and Critical Care, 2021
Background In the United States, nearly 25,000 patients annually undergo percutaneous ventriculostomy for the management of increased intracranial pressure with little consensus on extraventricular drain management.
Corey Engel, Amanda L. Faulkner, David W. Van Wyck, Ali R. Zomorodi, Nicolas K. Kam King, Rachel A. Williamson Taylor, Claire E. Hailey, Odera A. Umeano, David L. McDonagh, Yi-Ju Li, Michael L. James   +10 more
doaj   +1 more source

Galactokinase 1 Positively Regulates Mitochondrial Respiration by Phosphorylating TIMM13 as a Protein Kinase

Advanced Science, EarlyView.
GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko, Dongyoon Shin, Junho Park, June Huh, Youngsoo Kim, Jong‐Wan Park   +5 more
wiley   +1 more source

Computer-driven automated weaning reduces weaning duration in difficult-to-wean patients

Chinese Medical Journal, 2013
Background Weaning difficulties occur in 31% of total intubated patients, and result in prolonged weaning duration. A computer-driven automated weaning system can perform a spontaneous breathing trial (SBT) automatically and display a message when the trial is successfully passed. Such a system might have a beneficial effect on
Ling, Liu, Xiao-Ting, Xu, Yi, Yang, Ying-Zi, Huang, Song-Qiao, Liu, Hai-Bo, Qiu   +5 more
openaire   +2 more sources

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Evaluation of growth performance and gastro-intestinal parameters on the response of weaned piglets to dietary organic acids

Anais da Academia Brasileira de Ciências, 2018
Two experiments (E) were carried out to evaluate the effects of fumaric acid and an acidifier blend [composed by calcium formate, calcium lactate and medium-chain fatty acids (capric and caprylic)] in piglet diets containing colistin (40 ppm) or ...
HENRIQUE A.T. GRECCO, ALESSANDRO B. AMORIM, MAYRA A.D. SALEH, MARCOS L.P. TSE, FILIPE G. TELLES, GABRIELA M. MIASSI, GUILHERME M. PIMENTA, DIRLEI A. BERTO   +7 more
doaj   +1 more source