Results 101 to 110 of about 525,186 (281)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

On the Origins of Toughness in Corymbia calophylla (Marri Tree) Nuts

Advanced Science, EarlyView.
We uncover the natural toughening mechanisms of the marri nut, including fiber pullout, crack deflection, and a viscoelastic matrix, which enable exceptional energy absorption and ductility comparable to Teflon, with an elastic modulus similar to acrylic.
Wegood M. Awad, Ahmed S. Dalaq, Marieh B. Al‐Handawi, Rezo Getsadze, Oraib Al‐Ketan, James Weston, Mohammed Daqaq, Panče Naumov   +7 more
wiley   +1 more source

A User-Centric WS-Mediator Framework for on-the-fly Web Service Composition [PDF]

Telfor Journal, 2012
Nowadays, the effective and adaptive dynamic Web service composition is a major challenge for a real success of Web services among ordinary users. For the latter, and from the viewpoint of a user centric paradigm, existing work has limitation on their ...
T. Zhang, K. Chen
doaj  

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Dynamic Web Service Selection for Reliable Web Service Composition

IEEE Transactions on Services Computing, 2008
This paper studies the dynamic web service selection problem in a failure-prone environment, which aims to determine a subset of Web services to be invoked at run-time so as to successfully orchestrate a composite web service. We observe that both the composite and constituent web services often constrain the sequences of invoking their operations and ...
HWANG, San-Yih, LIM, Ee Peng, LEE, Chien-Hsiang, CHEN, Cheng-Hung   +3 more
openaire   +3 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

QoS-aware web service composition using Gray Wolf Optimizer

International Journal of Information and Communication Technology Research, 2017
In a service-oriented application, an integrated model of web services is composed of multiple abstract tasks. Each abstract task denotes a certain functionality that could be executed by a number of candidate web services with different qualities.
Meysam Karimi, Seyed Morteza Babamir
doaj  

Improving Semantic Web Services Composition Performance, Using Data Mining Techniques

Journal of Algorithms & Computational Technology, 2010
There are many usages for the Web services in the World Wide Web. For creating new services we can compose other developed services in the way we want to use them.
Shahab Bayati, Ardeshir Bahreininejad, Ali Farahmand Nejad, Ssdegh Kharazmi   +3 more
doaj   +1 more source

Service Management for IoT: Requirements, Taxonomy, Recent Advances and Open Research Challenges

IEEE Access, 2019
The exponential growth in the number of smart devices connected to the Internet of Things (IoT), and associated with various IoT-based smart applications and services, raises interoperability challenges which could affect the sustainability of IoT ...
Abdelmuttlib Ibrahim Abdalla Ahmed, Abdullah Gani, Siti Hafizah Ab Hamid, Abdelzahir Abdelmaboud, Hassan Jamil Syed, Riyaz Ahamed Ariyaluran Habeeb Mohamed, Ihsan Ali   +6 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source