Results 51 to 60 of about 3,051,054 (296)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Hacia una web social libre y federada: el caso de Lorea

Revista Teknokultura, 2012
Este artículo aborda las limitaciones de la web 2.0, las claves para superarlas y las recientes iniciativas de web social libre y federada. De entre ellas nos centraremos en el caso de Lorea desde nuestra experiencia directa con ella.
Florencio Cabello, Marta G. Franco, Alex Haché   +2 more
doaj   +2 more sources

Googling social interactions: web search engine based social network construction. [PDF]

PLoS ONE, 2010
Social network analysis has long been an untiring topic of sociology. However, until the era of information technology, the availability of data, mainly collected by the traditional method of personal survey, was highly limited and prevented large-scale ...
Sang Hoon Lee, Pan-Jun Kim, Yong-Yeol Ahn, Hawoong Jeong   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Permuting Web and Social Graphs [PDF]

Internet Mathematics, 2009
Abstract Since the first investigations on web-graph compression, it has been clear that the ordering of the nodes of a web graph has a fundamental influence on the compression rate (usually expressed as the number of bits per link). The authors of the LINK database [Randall et al.
P. Boldi, M. Santini, S. Vigna
openaire   +2 more sources

Towards Social Information Seeking and Interaction on the Web [PDF]

, 2009
User generated content is one of the key concepts of the social web (a. k. a “Web 2.0”) and enables users to search and interact with information that has been created (e.g. blogs) or annotated by other users (e.g. in tagging systems).
Heckner, Markus, Wolff, Christian
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Tareas 2.0: la dimensión digital en el aula de español lengua extranjera [PDF]

marcoELE. Revista de Didáctica Español Lengua Extranjera, 2009
En este artículo los autores han buscado establecer una comparativa entre las características básicas de las nuevas aplicaciones de la web social y el proceso de enseñanza y aprendizaje de una segunda lengua, haciendo especial hincapié en las actitudes y
Herrera, Francisco, Conejo, Emilia
doaj  

When the Social Meets the Semantic: Social Semantic Web or Web 2.5

Future Internet, 2012
The social trend is progressively becoming the key feature of current Web understanding (Web 2.0). This trend appears irrepressible as millions of users, directly or indirectly connected through social networks, are able to share and exchange any kind of
Salvatore F. Pileggi, Vicente Traver, Carlos Fernandez-Llatas   +2 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source