Results 171 to 180 of about 31,428 (237)

Ribociclib is not a substrate or inhibitor of Oatp1b-mediated uptake in vivo. [PDF]

Cancer Chemother Pharmacol
Drabison T, Ahmed EA, Colasanti N, Weber RH, Sparreboom A, Eisenmann ED.   +5 more
europepmc   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Rupture of a Nonaneurysmal Left Sinus of Valsalva Into the Pericardium. [PDF]

JACC Case Rep
Bidilean SA, Keller L, Ouda A, Rodriguez Cetina Biefer H, Risteski P, Dzemali O, Weber L, Linka A.   +7 more
europepmc   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

A New Customizable Surfactant LLPS Strategy for Sustainable and Highly Efficient Radioactive Metal Ion Separation

Advanced Science, EarlyView.
A diluent‐free, customizable liquid–liquid phase separation (LLPS) platform enables highly efficient radioactive metal ion extraction and stripping. By encapsulating hydrophobic extractants into an ionic surfactant‐rich condensed phase, this LLPS system leverages synergistic electrostatic and coordination interactions.
Ruihan Yan, Yifu Hu, Wentao Wang, Zhi Cao, Meiwen Cao, Weifang Zheng, Guoan Ye, Taihong Yan   +7 more
wiley   +1 more source

Associations Between Sustained Methamphetamine/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV. [PDF]

J Am Heart Assoc
Riley ED, Ma Y, Wu KC, Shitole SG, Neilands TB, Martinez C, Vidot D, Carrico A, Chandran A, Rodriguez CJ, Lazar J, Merenstein D, Floris-Moore M, Foster A, Weber KM, Tien PC, Kizer JR.   +16 more
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Fate of isoprene peroxy radical constrains the urban photochemical regime. [PDF]

Sci Adv
Robinson MA, Coggon MM, Bates KH, Peischl J, Jernigan CM, Novak G, Thakali S, Roberts JM, Neuman JA, Veres PR, Zuraski K, Waxman EM, Chace WS, Rollins AW, Treadaway V, Selby M, Francoeur C, Gilman JB, Liu S, Delaria ER, Sebol AE, Desai NS, Kaiser J, Kautzman KE, St Clair JM, Wolfe GM, Xu L, Stockwell CE, Warneke C, Huynh HN, Lyu M, Ahern A, Brock CA, Piasecki A, Albertin S, Middlebrook AM, Sullivan AP, Mohan MK, Weber R, Lill E, Pollack I, Ball K, Crounse JD, Wennberg PO, Novelli A, Stainsby A, Fuchs H, Bohn B, Gkatzelis GI, DiGangi JP, Diskin GS, Acdan JJM, Pierce RB, Hsu CH, Wang S, Schwantes R, Abad GG, Nowlan CR, Liu X, Howard N, Brown SS.   +60 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Risk Assessment of Delayed Graft Function in Pediatric Kidney Transplantation - a CERTAIN Research Network Analysis. [PDF]

Transpl Int
Patry C, Boßung M, Feißt M, Krupka K, Höcker B, Pape L, Kanzelmeyer N, Weber LT, Oh J, Awan A, Simon T, Peruzzi L, Duzova A, Kim JJ, Shenoy M, Schmitt CP, Fichtner A, Tönshoff B.   +17 more
europepmc   +1 more source