Results 181 to 190 of about 31,478 (238)

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Risk Assessment of Delayed Graft Function in Pediatric Kidney Transplantation - a CERTAIN Research Network Analysis. [PDF]

Transpl Int
Patry C, Boßung M, Feißt M, Krupka K, Höcker B, Pape L, Kanzelmeyer N, Weber LT, Oh J, Awan A, Simon T, Peruzzi L, Duzova A, Kim JJ, Shenoy M, Schmitt CP, Fichtner A, Tönshoff B.   +17 more
europepmc   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

The Fraction of Carbon in Soil Organic Matter as a National-Scale Soil Process Indicator. [PDF]

Glob Chang Biol
Reinsch S, Lebron I, de Jonge LW, Weber PL, Norgaard T, Arthur E, Gomes L, Pesch C, Konstantinos K, Zalidis G, Epelde L, Romic M, Romic D, Zovko M, Reljic M, Heikkinen J, Feeney C, Bentley L, Levy P, Vanguelova E, Panagos P, Schneider F, Ahrens B, Leifeld J, Hugelius G, Emmett BA, Cosby BJ, Brentegani M, Tandy S, Thomas A, van Soest MAJ, Robinson DA.   +31 more
europepmc   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Alcohol-attributable cancer risk and burden estimates for Australia's updated alcohol consumption guidelines. [PDF]

Br J Cancer
Sarich P, Canfell K, Egger S, Banks E, Joshy G, Wellard-Cole L, Hughes C, Houssami N, Grogan P, Weber MF.   +9 more
europepmc   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Carbon monoxide oxidizers in soils of different ages from Piton de la Fournaise volcano. [PDF]

FEMS Microbiol Ecol
Wildbur C, Dawson RA, Roy S, Ah-Peng C, Espenberg M, Hernández M.   +5 more
europepmc   +1 more source