Results 161 to 170 of about 1,060,192 (320)

Websites of Note

open access: yesThe Electrochemical Society Interface, 2016
openaire   +1 more source

Controllable Generation of Pathogen‐Specific Antimicrobial Peptides Through Knowledge‐Aware Prompt Diffusion Model

open access: yesAdvanced Science, EarlyView.
KPPepGen is a knowledge‐aware prompt diffusion model for the controllable generation of pathogen‐specific AMPs. It outperforms existing methods and is capable of simultaneously generating peptides for distinct pathogens, demonstrating superior performance with favorable properties and docking efficacy.
Yongkang Wang   +4 more
wiley   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

open access: yesAdvanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng   +7 more
wiley   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

open access: yesAdvanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao   +18 more
wiley   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

open access: yesAdvanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu   +14 more
wiley   +1 more source

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