Inhibition mechanism and behaviour of wedelolactone against α-glucosidase [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryThe quest for effective and safe treatments for diabetes mellitus has led to the exploration of natural metabolites as potential α-glucosidase inhibitors.
Jianjun Zhang +4 more
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Enhanced wedelolactone content in in vitro-raised genetically uniform Wedelia chinensis under the influence of CuSO4 [PDF]
Frontiers in Plant Science, 2023 In the present study, we addressed the imperative for potent anticancer agents through Wedelia chinensis, a medicinal plant abundant in the robust antihepatotoxic and antitumor compound wedelolactone. Hindrances in conventional propagation methods due to
Ravi Kant Swami +3 more
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Regulating mitochondrial oxidative phosphorylation and MAPK signaling: wedelolactone as a novel therapeutic for radiation-induced thrombocytopenia [PDF]
Frontiers in PharmacologyIntroductionRadiation-induced thrombocytopenia (RIT) is a serious complication of cancer radiotherapy, for which therapeutic options are limited. This study investigates wedelolactone (WED), a metabolite of a botanical drug, as a potential treatment for ...
Zhichao Li +13 more
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In Silico Study of Coumarins: Wedelolactone as a Potential Inhibitor of the Spike Protein of the SARS-CoV-2 Variants [PDF]
Journal of Tropical Medicine, 2023 Despite the rigorous global efforts to control SARS-CoV-2 transmission, it continues to pose a serious threat to humans with the frequent emergence of new variants. Thus, robust therapeutics to combat the virus are a desperate need. The SARS-CoV-2 spike (
Saurav Katuwal +8 more
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Wedelolactone, a natural coumestan with multiple pharmacological effects [PDF]
Frontiers in PharmacologyNatural products, especially those from medicinal plants, have been increasingly attractive to researchers. Wedelolactone (WL) is a natural coumestan that was first isolated from Wedelia Chinensis.
Shanshan Han +3 more
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Exploring the Multitarget Activity of Wedelolactone against Alzheimer’s Disease: Insights from In Silico Study [PDF]
ACS Omega, 2023 In this study, Wedelolactone’s multitarget activity against Alzheimer’s disease was examined using density functional theory and molecular docking techniques. At physiological pH, the pKa and molar fractions have been estimated.
Dang Xuan Du +4 more
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Natural phenolic compounds as biofilm inhibitors of multidrug-resistant Escherichia coli – the role of similar biological processes despite structural diversity [PDF]
Frontiers in Microbiology, 2023 Multidrug-resistant gram-negative pathogens such as Escherichia coli have become increasingly difficult to treat and therefore alternative treatment options are needed.
David Buchmann +9 more
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UPLC-QTOF-MS-based lipidomic study of wedelolactone in acute colitis mice induced by dextran sulfate sodium [PDF]
Heliyon, 2023 Inflammatory bowel disease is a relapsing inflammatory disease seriously endanger human health. Wedelolactone (WED) is a major active ingredient from Eclipta prostrata (L.) L. and has shown anti-inflammatory effects.
Yuanyuan Gou +7 more
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Wedelolactone induces pyroptosis to suppress retinoblastoma by inhibiting the Nrf2/Keap1 signaling pathway. [PDF]
Med OncolRetinoblastoma is an intraocular malignancy with limited therapeutic options, imposing a severe health burden on young patients. Wedelolactone (WDL), a natural product from E.
Jiang Y +6 more
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Wedelolactone attenuates cerebral ischemia-reperfusion injury by blocking GPX4-mediated ferroptosis [PDF]
Journal of Men's Health, 2023 Cerebral ischemia is currently the third leading cause of death worldwide. Among its complications, cerebral ischemia-reperfusion (I/R) is considered the most inevitable problem.
Huyin Yang, Dai Liu, Yanping Wang
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