The Role of Caspase-11 and Pyroptosis in the Regulation of Inflammation in Peri-Implantitis [PDF]
Journal of Inflammation Research, 2023 Pengcheng Jiao,1,* Zuntai Li,2,* Birong Li,3 Xingyuan Jiao4 1Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 2Hospital of Stomatology, Jilin University, Changchun, Jilin, People’s Republic
Jiao P, Li Z, Li B, Jiao X
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Caspase-11–Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic SteatohepatitisSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background: Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH.
Yingwei Zhu +6 more
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Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11 [PDF]
Immunity, Inflammation and DiseaseBackground Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez +4 more
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Gemfibrozil mitigates caspase-11-driven myocardial pyroptosis in ischemia/reperfusion injury in mice [PDF]
Journal of Molecular and Cellular Cardiology PlusThe size of the infarct area following acute myocardial infarction (AMI) is a critical prognostic factor. Caspase-11-dependent pyroptosis has been implicated as a key mechanism driving cardiomyocyte death after AMI.
Tetsuro Marunouchi +3 more
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Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS [PDF]
eLifeInflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammasomes.
Daniel C Akuma +9 more
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Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury [PDF]
Molecular MedicineBackground Retinal ischemia/reperfusion (IR) injury is a common pathological process in many ophthalmic diseases. Interleukin-1β (IL-1β) is an important inflammatory factor involved in the pathology of retinal IR injury, but the mechanism by which IL-1β ...
Yong Wan +5 more
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1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells [PDF]
Frontiers in PharmacologyBackground1-Nitropyrene (1-NP) is harmful to the respiratory system and can evoke acute lung injury (ALI). Pyroptosis and apoptosis, two important types of programmed cell death, are involved in the pathological process of ALI.
Zhao-Lei Ding +21 more
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Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production [PDF]
Frontiers in ImmunologyIntroductionKlebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, the mechanisms underlying K.
Yuqi Zhou +8 more
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Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus [PDF]
MedCommNoncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of pyroptosis in SLE pathogenesis remains unclear ...
Yue Xin +4 more
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Cell Reports, 2021 Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby +13 more
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