Results 41 to 50 of about 4,547,686 (290)

Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases

Journal of Neuroinflammation, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
doaj   +1 more source

Shigella OspC3 suppresses murine cytosolic LPS sensing

iScience, 2021
Summary: Shigella flexneri, a cytosol-invasive gram-negative pathogen, deploys an array of type III-secreted effector proteins to evade host cell defenses.
Changhoon Oh, Ambika Verma, Mohib Hafeez, Brandon Hogland, Youssef Aachoui   +4 more
doaj   +1 more source

Caspase-11 Protects Against Bacteria That Escape the Vacuole [PDF]

Science, 2013
Caspase-11–Dependent Pyroptosis Inflammasomes are multiprotein complexes that assemble to initiate immunity to a variety of microorganisms, as well as to sterile tissue injury. Although a role for caspase-1 downstream of inflammasomes is well characterized, the discovery that caspase-1 knockout mice were also deficient in caspase-
Youssef, Aachoui, Irina A, Leaf, Jon A, Hagar, Mary F, Fontana, Cristine G, Campos, Daniel E, Zak, Michael H, Tan, Peggy A, Cotter, Russell E, Vance, Alan, Aderem, Edward A, Miao   +10 more
openaire   +2 more sources

Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease

Frontiers in Pharmacology, 2022
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract, associated with high levels of inflammatory cytokine production.
Aoife P. Smith, Emma M. Creagh
doaj   +1 more source

Caspase-11 effector functions and models for caspase-11 activation. [PDF]

, 2013
(A) Caspase-11 effector functions. Active caspase-11 cooperates with components of the NLRP3 inflammasome to induce caspase-1-dependent maturation of pro-IL-1β and pro-IL-18.
Denise M. Monack (243058), Petr Broz (383934)   +1 more
core   +1 more source

Caspase-3/-6/-8 are required for Gsdme-dependent pyroptosis. [PDF]

, 2022
a Images and cell viability of WT, Nlrp3-/-, Caspase-1-/- and Gsdmd-/- BMDMs left untreated or stimulated with ATP and silica. Arrowheads indicate pyroptotic cells. The scale bar represents 100 μm.
Yujie Zou (408340), Yaqiong Tian (6309854), Peiliang Shi (2617767), Lulu Kang (684986), Ji Zhang (70438), Visarut Codey Buranasudja (14209915), Jinghong Dai (13848544), Jingwen Pei (5626415), Xiang Gao (4077), Hourong Cai (6309875), Zhaoyu Lin (170763), Yufang Wang (105742), Jingyu Chen (3571688)   +12 more
core   +1 more source

Listeria monocytogenesInfection in Caspase-11-Deficient Mice [PDF]

Infection and Immunity, 2002
ABSTRACTCaspase-11 (Cas11) is a cysteine protease involved in programmed cell death and cytokine maturation. Through activation of Cas1 (interleukin-1β [IL-1β]-converting enzyme), Cas11 is directly involved in the maturation of IL-1β and IL-18. Apoptosis is mediated through Cas3.
Mueller, Nicholas J., Wilkinson, Robert A., Fishman, Jay   +2 more
openaire   +4 more sources

Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]

, 2011
IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer, Clemens D Cohen, Vielhauer, V, Lichtnekert Julia, Dan Muruve, Shrikant R. Mulay, Muruve, D, Ramanjaneyulu Allam, Maja T. Lindenmeyer, Lichtnekert, Julia, Hans-Joachim Anders, Lindenmeyer, M T, Cohen Clemens D., Kulkarni, Onkar P., Vielhauer, Volker, Muruve Dan, Kulkarni Onkar P., Maja T Lindenmeyer, Cohen, Clemens D., Ryu, Mi, Rupanagudi Khader Valli, Ryu Mi, Khader Valli Rupanagudi, Mulay Shrikant R., Ryu, M, Lindenmeyer, Maja T., Anders Hans-Joachim, Clemens D. Cohen, Cohen, C D, Onkar P Kulkarni, Shrikant R Mulay, Allam, R, Allam Ramanjaneyulu, Vielhauer Volker, Muruve, Dan, Rupanagudi, Khader Valli, Anders, Hans-Joachim, Mi Ryu, Lichtnekert, J, Mulay, Shrikant R., Allam, Ramanjaneyulu, Julia Lichtnekert, Lindenmeyer Maja T., Rupanagudi, K V, Mulay, S R, Kulkarni, O P, Anders, H J, Onkar P. Kulkarni   +47 more
core   +1 more source

Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

Cell & Bioscience, 2019
Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical ...
Xiaoli Huang, Yang Feng, Guanqing Xiong, Shona Whyte, Jing Duan, Yucen Yang, Kaiyu Wang, Shiyong Yang, Yi Geng, Yangping Ou, Defang Chen   +10 more
doaj   +1 more source

Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis [PDF]

, 2019
The granulomatous lesion resulting from infection with the fungus Paracoccidioides brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a fibroblast- and collagen-rich content.
Luciana Benevides, Natália Ketelut-Carneiro, Camila Oliveira Silva Souza, Luiz Gustavo Gardinassi (3340488), Maria Cláudia Silva, Luciana Benevides (462569), Lucas Alves Tavares, Camila Oliveira Silva Souza (7274627), Luiz Gustavo Gardinassi, João Santana Silva, Natália Ketelut-Carneiro (7274624), Maria Cláudia Silva (7274630), Dario Simões Zamboni, Dario Simões Zamboni (7274636), João Santana Silva (7274639), Lucas Alves Tavares (7274633)   +15 more
core   +1 more source