Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. [PDF]
Nat Immunol, 2022 Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent bacteria do not invade the cytosol, their presence in tissues necessitates clearance and immune system mobilization.
Moretti J +9 more
europepmc +3 more sources
Pyroptotic and non‐pyroptotic effector functions of caspase‐11 [PDF]
Immunological Reviews, 2020 AbstractInnate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response. Inflammasomes are highly sophisticated and effective orchestrators of innate immunity.
Arwa Abu Khweek, Amal O. Amer
openaire +2 more sources
Pyroptosis: Caspase-11 Unlocks the Gates of Death [PDF]
Immunity, 2015 How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
de Gassart A, Martinon F
openaire +3 more sources
Regulation, Activation and Function of Caspase-11 during Health and Disease [PDF]
International Journal of Molecular Sciences, 2021 Caspase-11 is a pro-inflammatory enzyme that is stringently regulated during its expression and activation. As caspase-11 is not constitutively expressed in cells, it requires a priming step for its upregulation, which occurs following the stimulation of pathogen and cytokine receptors.
Agnew, Aidan +2 more
openaire +2 more sources
Caspase-2S relative mRNA expression levels in neurological disease. [PDF]
, 2022 (A) Caspase-2S mRNA expression levels trend lower in AD but not MCI compared to CN controls. Caspase-2S mRNA do not differ in LBD (B) or HD (C) compared to controls.
Ronald C. Petersen (9562700) +5 more
core +1 more source
Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases. [PDF]
Int J Mol SciInflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which were discovered first and are activated in response to a variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and non ...
Yi YS.
europepmc +3 more sources
Caspase-11 controls pyroptosis of lung epithelial cells. [PDF]
, 2018 (A) TC-1 cells were infected with B. thailandensis or the bsaZ mutant in presence or absence of IFNγ. Active caspase-11 was pulled-down from cell lysates using Biotin-VAD-FMK and detected by immunoblot.
Fabio Re (189981) +6 more
core +1 more source
Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]
, 2014 The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J +11 more
core +1 more source
Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney
Frontiers in Surgery, 2021 Brain death (BD) induces an organ-level inflammatory response. However, the underlying mechanisms have not been fully elucidated. Here, we investigated the role of caspase-1-mediated pyroptosis in BD-induced kidney injury in rats.
Weifeng Liu +21 more
doaj +1 more source
Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]
, 2013 We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana +12 more
core +1 more source