Results 31 to 40 of about 4,545,902 (287)

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Cell Reports, 2021
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant   +13 more
doaj   +1 more source

Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria

Frontiers in Immunology, 2022
Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Edward A. Miao, Edward A. Miao, Edward A. Miao   +6 more
doaj   +1 more source

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Frontiers in Cellular and Infection Microbiology, 2023
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang   +10 more
doaj   +1 more source

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nature, 2015
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1b processing, and ...
O'Rourke, Karen, Irma B. Stowe, Scott J. Snipas, Juan Zhang, Salvesen, Guy, Peter S. Liu, Liu, Peter, Fitzgerald, Linda, Zhang, Juan, Benjamin Haley, Yafei Zhang, Warming, Søren, Lucy X. Morris, Kummerfeld, Sarah, Keith Anderson, Goodnow, Christopher, Wu, Jiansheng, Edward M. Bertram, Jennie R. Lill, Karen O’Rourke, Li, Hong, Haley, Benjamin, Sarah Kummerfeld, Bettina L. Lee, Anderson, Keith, Vishva M. Dixit, Jiansheng Wu, Phung, Qui, Zhang, Yafei, Merone Roose-Girma, Kayagaki, Nobuhiko, Trinna Cuellar, Dixit, Vishva, Søren Warming, Lee, Bettina, Christopher C. Goodnow, Lill, Jennie, Wyne P. Lee, Bertram, Edward, Lee, Wyne, Guy S. Salvesen, Roose-Girma, Merone, Cuellar, Trinna, Morris, Lucy, Hong Li, Snipas, Scott, Qui T. Phung, Stowe, Irma, Nobuhiko Kayagaki, Linda Fitzgerald   +49 more
core   +4 more sources

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11 [PDF]

Nature, 2021
Mouse caspase-11 and human caspase-4 and caspase-5 recognize cytosolic lipopolysaccharide (LPS) to induce pyroptosis by cleaving the pore-forming protein GSDMD1-5. This non-canonical inflammasome defends against Gram-negative bacteria6,7. Shigella flexneri, which causes bacillary dysentery, lives freely within the host cytosol where these caspases ...
Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqiang Wang, Xiaofan Liu, Xuyan Shi, Yaxin Liu, Xiangbing Qi, Xiaoyun Liu, Jingjin Ding, Feng Shao   +12 more
openaire   +2 more sources

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

Cells, 2022
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget, Emilie Doz-Deblauwe, Nathalie Winter, Benoit Briard   +3 more
doaj   +1 more source

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

Cell Reports, 2020
Summary: Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)
Stephen B. Kovacs, Changhoon Oh, Vivien I. Maltez, Benjamin D. McGlaughon, Ambika Verma, Edward A. Miao, Youssef Aachoui   +6 more
doaj   +1 more source

Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. [PDF]

Nat Immunol, 2022
Caspase-11 detection of intracellular lipopolysaccharide (LPS) from invasive Gram-negative bacteria mediates noncanonical activation of the NLRP3 inflammasome. While avirulent bacteria do not invade the cytosol, their presence in tissues necessitates clearance and immune system mobilization.
Moretti J, Jia B, Hutchins Z, Roy S, Yip H, Wu J, Shan M, Jaffrey SR, Coers J, Blander JM.   +9 more
europepmc   +3 more sources

Caspase-11: The Noncanonical Guardian of Cytosolic Sanctity [PDF]

Cell Host & Microbe, 2013
Caspase-11 controls a noncanonical inflammasome that responds to Gram-negative bacteria and certain pore-forming toxins. Aachoui et al. (2013) and Case et al. (2013) identify a role for caspase-11 in rapid responses to bacterial pathogens that access the cytosol via vacuolar membrane disruption or the activity of specialized secretion systems.
Shin, Sunny, Brodsky, Igor E.
openaire   +2 more sources

Pyroptotic and non‐pyroptotic effector functions of caspase‐11 [PDF]

Immunological Reviews, 2020
AbstractInnate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response. Inflammasomes are highly sophisticated and effective orchestrators of innate immunity.
Arwa Abu Khweek, Amal O. Amer
openaire   +2 more sources