Results 1 to 10 of about 17,765 (201)

Non-Canonical Inflammasome Pathway: The Role of Cell Death and Inflammation in Ehrlichiosis [PDF]

Cells, 2023
Activating inflammatory caspases and releasing pro-inflammatory mediators are two essential functions of inflammasomes which are triggered in response to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs).
Aditya Kumar Sharma, Nahed Ismail
doaj   +6 more sources

A novel mechanism of Korean Red Ginseng-mediated anti-inflammatory action via targeting caspase-11 non-canonical inflammasome in macrophages [PDF]

Journal of Ginseng Research, 2022
Background: Korean Red Ginseng (KRG) was reported to play an anti-inflammatory role, however, previous studies largely focused on the effects of KRG on priming step, the inflammation-preparing step, and the anti-inflammatory effect of KRG on triggering ...
Ji-Hyun Min, Hui-Jin Cho, Young-Su Yi
doaj   +4 more sources

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages [PDF]

Nature Communications, 2018
Non-canonical inflammasome activation is mediated by caspase-11 in mice and caspase-4 in humans. Here the authors show that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) competes with LPS for binding to these caspases and in
Lan H. Chu, Mohanalaxmi Indramohan, Rojo A. Ratsimandresy, Anu Gangopadhyay, Emily P. Morris, Denise M. Monack, Andrea Dorfleutner, Christian Stehlik   +7 more
doaj   +3 more sources

Hepatocytes Are Resistant to Cell Death From Canonical and Non-Canonical Inflammasome-Activated PyroptosisSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background: Pyroptosis, gasdermin-mediated programmed cell death, is readily induced in macrophages by activation of the canonical inflammasome (caspase-1) or by intracellular lipopolysaccharide (LPS)-mediated non-canonical inflammasome (caspase-11 ...
Ping Sun, Jie Zhong, Hong Liao, Patricia Loughran, Joud Mulla, Guang Fu, Da Tang, Jie Fan, Timothy R. Billiar, Wentao Gao, Melanie J. Scott   +10 more
doaj   +5 more sources

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome [PDF]

Cell Reports, 2019
Summary: Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of leishmaniasis, a disease that affects millions of people worldwide.
Renan V.H. de Carvalho, Warrison A. Andrade, Djalma S. Lima-Junior, Marisa Dilucca, Caroline V. de Oliveira, Kun Wang, Paula M. Nogueira, Jeronimo N. Rugani, Rodrigo P. Soares, Stephen M. Beverley, Feng Shao, Dario S. Zamboni   +11 more
doaj   +6 more sources

The Protective Effects of Goitrin on LPS-Induced Septic Shock in C57BL/6J Mice via Caspase-11 Non-Canonical Inflammasome Inhibition [PDF]

Molecules, 2023
Septic shock is defined as a subset of sepsis, which is associated with a considerably high mortality risk. The caspase-11 non-canonical inflammasome is sensed and activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis, it plays a ...
Deqing Ruan, Jingyi Yang, Qianfei Luo, Yanhong Shi, Lili Ding, Zhengtao Wang, Rui Wang, Li Yang   +7 more
doaj   +2 more sources

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria [PDF]

mBio
The NLRP11 protein is only expressed in primates and participates in the activation of the canonical NLRP3 and non-canonical NLRP3 inflammasome activation after infection with gram-negative bacteria. Here, we generated a series of defined NLRP11 deletion
Mateusz Szczerba, Akshaya Ganesh, María Luisa Gil-Marqués, Volker Briken, Marcia B. Goldberg   +4 more
doaj   +2 more sources

NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages [PDF]

eLife
Septic shock is characterized by an excessive inflammatory response depicted in a cytokine storm that results from invasive bacterial, fungi, protozoa, and viral infections.
Jasper Iske, Rachid El Fatimy, Yeqi Nian, Amina Ghouzlani, Siawosh K Eskandari, Hector Rodriguez Cetina Biefer, Anju Vasudevan, Abdallah Elkhal   +7 more
doaj   +2 more sources

The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage [PDF]

Frontiers in Immunology, 2023
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections to carry out pyroptosis.
Mohamed Ghait, Shivalee N. Duduskar, Michael Rooney, Michael Rooney, Norman Häfner, Laura Reng, Bianca Göhrig, Philipp A. Reuken, Frank Bloos, Michael Bauer, Michael Bauer, Christoph Sponholz, Tony Bruns, Tony Bruns, Ignacio Rubio, Ignacio Rubio   +15 more
doaj   +2 more sources

Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii [PDF]

Communications Biology
Multidrug-resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to their resistance to last resort carbapenem and polymyxin antibiotics.
Fei-Ju Li, Lora Starrs, Anukriti Mathur, Daniel Enosi Tuipulotu, Si Ming Man, Gaetan Burgio   +5 more
doaj   +2 more sources