Results 31 to 40 of about 17,765 (201)
Caspase-11 Non-canonical Inflammasomes in the Lung [PDF]
Frontiers in Immunology, 2020 The airway epithelium and underlying innate immune cells comprise the first line of host defense in the lung. They recognize pathogen-associated molecular patterns (PAMPs) using membrane-bound receptors, as well as cytosolic receptors such as inflammasomes. Inflammasomes activate inflammatory caspases, which in turn process and release the inflammatory
Changhoon Oh +2 more
openaire +3 more sources
Canonical and non-canonical functions of NLRP3
Journal of Advanced Research, 2023 Background: Since its discovery, NLRP3 is almost never separated from its major role in the protein complex it forms with ASC, NEK7 and Caspase-1, the inflammasome.
Théo Accogli +2 more
doaj +1 more source
Frontiers in Immunology, 2021 Non-canonical inflammasome activation by mouse caspase-11 (or human CASPASE-4/5) is crucial for the clearance of certain gram-negative bacterial infections, but can lead to severe inflammatory damage.
Debabrata Chowdhury +9 more
doaj +1 more source
Frontiers in Immunology, 2023 NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death.
Marie-Laure Clénet +7 more
doaj +1 more source
Frontiers in Immunology, 2020 Bacteria-released components can modulate host innate immune response in the absence of direct host cell–bacteria interaction. In particular, bacteria-derived outer membrane vesicles (OMVs) were recently shown to activate host caspase-11-mediated non ...
Jungmin Yang +6 more
doaj +1 more source
Pathogens, 2020 Brucella abortus is a zoonotic pathogen that causes brucellosis. Because of Brucella’s unique LPS layer and intracellular localization predominately within macrophages, it can often evade immune detection.
Juselyn D. Tupik +6 more
doaj +1 more source
Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases. [PDF]
Immune Netw, 2018 Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes - multiprotein oligomers comprising intracellular pattern recognition receptors and inflammatory effectors - such as ASC and pro-cysteine-aspartic ...
Yi YS.
europepmc +4 more sources
Cell Reports, 2023 Summary: Activating the macrophage NLRP3 inflammasome can promote excessive inflammation with severe cell and tissue damage and organ dysfunction.
Allison K. Meyers +17 more
doaj +1 more source
Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation
Frontiers in Immunology, 2020 The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu +5 more
doaj +1 more source
Secretoglobin 3A2 eliminates human cancer cells through pyroptosis
Cell Death Discovery, 2021 Non-canonical inflammasome activation that recognizes intracellular lipopolysaccharide (LPS) causes pyroptosis, the inflammatory death of innate immune cells.
Shigetoshi Yokoyama +4 more
doaj +1 more source