Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48. [PDF]
EBioMedicineHereditary spastic paraplegia (HSP) denotes a heterogeneous group of neurodegenerative spastic gait disorders. Variants in SPG11 cause the most common autosomal recessive HSP also known as SPG11. The gene product Spatacsin interacts with the adaptor protein complex 5 (AP5). Because neurodegeneration in SPG11 is accompanied by marked neuro-inflammation,
Afzal MA +13 more
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Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages. [PDF]
Int J Mol Sci, 2023 Cho HJ, Kim E, Yi YS.
europepmc +2 more sources
Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases. [PDF]
Int J Mol Sci, 2023 Yi YS.
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Size matters in non-canonical inflammasome activation and cell-mediated immunity. [PDF]
Cell Rep Med, 2023 Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al.1 find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant technologies.
Weiss AM, Esser-Kahn AP.
europepmc +3 more sources
TYK2 licenses non-canonical inflammasome activation during endotoxemia. [PDF]
Cell Death Differ, 2021 The non-canonical inflammasome is an emerging crucial player in the development of inflammatory and neurodegenerative diseases. It is activated by direct sensing of cytosolic lipopolysaccharide (LPS) by caspase-11 (CASP11), which then induces pyroptosis, an inflammatory form of regulated cell death.
Poelzl A +12 more
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Caspase-11 Non-Canonical Inflammasome: Emerging Activator and Regulator of Infection-Mediated Inflammatory Responses. [PDF]
Int J Mol Sci, 2020 Yi YS.
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IRF1 and IRF2 regulate the non-canonical inflammasome. [PDF]
EMBO Rep, 2019 The non-canonical inflammasome mediates pyroptotic cell death in response to bacterial lipopolysaccharide (LPS) found in the cytosol. Understanding the mechanism and regulation of this system is of great interest, given its central role in mouse models of bacterial septic shock. In this issue of EMBO Reports, Benaoudia and colleagues sought to discover
Thygesen SJ, Stacey KJ.
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TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD [PDF]
Immunity, Inflammation and DiseaseBackground Non‐alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder driven by inflammation, in which the NLRP3 inflammasome plays a central role.
Yanxia Zhang
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Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation. [PDF]
Antioxidants (Basel), 2022 Maltol (3-hydroxy-2-methyl-4-pyrone) is used widely as a food and cosmetic supplement, and it has antioxidant and anti-inflammatory activities. Inflammasome causes the maturation and secretion of interleukin (IL)-1β and -18 through the activation of caspase-1 (Casp1), which contributes to various inflammatory diseases.
Ahn H, Lee G, Han BC, Lee SH, Lee GS.
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Non-canonical inflammasome activation analysis in a mouse model of Citrobacter rodentium infection. [PDF]
STAR Protoc, 2022 Infection of mice with Citrobacter rodentium is a useful model for studying the pathogenicity of enteropathogenic and enterohemorrhagic Escherichia coli, pathogens that have a close association with humans. Here, we provide a protocol detailing the approaches for non-canonical inflammasome analysis in a mouse model of C.
Tsutsuki H +4 more
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