Results 41 to 50 of about 17,765 (201)
Scientific Reports, 2017 Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation,
Huijeong Ahn +7 more
doaj +1 more source
Cell Reports, 2018 Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Jaye M. Platnich +17 more
doaj +1 more source
Pathogens, 2020 Ischemia reperfusion injury (IRI) during liver transplantation increases morbidity and contributes to allograft dysfunction. There are no therapeutic strategies to mitigate IRI.
Alexander M. Fagenson +13 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The abnormal activation of the NLRP3 inflammasome is closely related to the occurrence and development of many inflammatory diseases. Targeting the NLRP3 inflammasome has been considered an efficient therapy to treat infections.
Ziying Wei +27 more
doaj +1 more source
Tivantinib alleviates inflammatory diseases by directly targeting NLRP3
iScience, 2023 Summary: NLRP3 inflammasome-mediated immune responses are involved in the pathogenesis of multiple inflammatory diseases, but few clinical drugs are identified that directly target the NLRP3 inflammasome to treat these diseases to date.
Yi Huang +6 more
doaj +1 more source
Caspase-11, the Main Executioner in Non-canonical Inflammasome [PDF]
Journal of Bacteriology and Virology, 2012 Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis.
Zahid Manzoor, Young-Sang Koh
openaire +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Emerging mechanisms and functions of inflammasome complexes in teleost fish
Frontiers in Immunology, 2023 Inflammasomes are multiprotein complexes, which are assembled in response to a diverse range of exogenous pathogens and endogenous danger signals, leading to produce pro-inflammatory cytokines and induce pyroptotic cell death.
Ming Xian Chang +2 more
doaj +1 more source
Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis [PDF]
Nephrology Dialysis Transplantation, 2013 NLRP-3 inflammasome is one of several intracellular danger recognition platforms that integrates infectious or non-infectious types of danger into the expression of pro-inflammatory cytokines to set-up inflammation for danger control. NLRP3 activation induces three types of caspase-1-mediated responses: secretion of IL-1beta, secretion of IL-18 and a ...
Georg, Lorenz +2 more
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Frontiers in Immunology, 2021 Inflammasomes are fundamental innate immune mechanisms that promote inflammation and induce an inflammatory form of programmed cell death, pyroptosis. Pyroptotic inflammasome has been reported to be closely associated with tumorigenesis and prognosis of ...
Ying Li +9 more
doaj +1 more source