Results 51 to 60 of about 17,765 (201)

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism [PDF]

Cell Reports, 2021
Abstract The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defences against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood.
Magnotti, Flora, Chirita, Daria, Dalmon, Sarah, Martin, Amandine, Bronnec, Pauline, Sousa, Jeremy, Helynck, Olivier, Lee, Wonyong, Kastner, Daniel L., Chae, Jae Jin, McDermott, Michael F., Belot, Alexandre, Popoff, Michel, Seve, Pascal, Georgin-Lavialle, Sophie, Munier-Lehmann, Helene, Tu, Anh Tran, De Langhe, Ellen, Wouters, Carine, Jamilloux, Yvan, Henry, Thomas   +20 more
openaire   +6 more sources

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Cell Stress, 2022
Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro ...
Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun   +5 more
doaj   +1 more source

Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation [PDF]

Scientific Reports, 2018
AbstractExposure to heavy metals can cause several diseases associated with the immune system. Although the effects of heavy metals on production of inflammatory cytokines have been previously studied, the role of heavy metals in inflammasome activation remains poorly studied.
Huijeong Ahn, Jeongeun Kim, Seung Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Geun-Shik Lee   +9 more
openaire   +2 more sources

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis

Frontiers in Immunology, 2022
Inflammasomes are multiprotein complexes that can sense danger signals and activate caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death.
Can Gan, Can Gan, Qiuyu Cai, Qiuyu Cai, Chengwei Tang, Chengwei Tang, Jinhang Gao, Jinhang Gao   +7 more
doaj   +1 more source

Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson’s disease

Journal of Neuroinflammation, 2022
Background Parkinson’s disease (PD) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation.
Adrianne F. Pike, Francesca Longhena, Gaia Faustini, Jean-Marc van Eik, Iris Gombert, Maaike A. C. Herrebout, Mona M. H. E. Fayed, Michele Sandre, Tatiana Varanita, Charlotte E. Teunissen, Jeroen J. M. Hoozemans, Arianna Bellucci, Robert Veerhuis, Luigi Bubacco   +13 more
doaj   +1 more source

The noncanonical inflammasome in health and disease

Infectious Medicine, 2022
Innate immune signaling plays a significant role in the rapid cellular responses against foreign entities. An inflammasome is a large cytosolic polymer of a pattern recognition receptor with/without an adaptor protein, formed in response to these ...
Jason Cahoon, Duomeng Yang, Penghua Wang
doaj   +1 more source

The Role of the NLRP3 Inflammasome in Mediating Glomerular and Tubular Injury in Diabetic Nephropathy

Frontiers in Physiology, 2022
The NOD-like receptor protein 3 (NLRP3) inflammasome is a multi-protein signalling complex integral to the chronic inflammatory response, activated in response to sterile and non-sterile cellular damage.
B. M. Williams, C. L. Cliff, K. Lee, P. E. Squires, C. E. Hills   +4 more
doaj   +1 more source

Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. [PDF]

Sci Rep, 2015
AbstractDeregulation of inflammasome activation was recently identified to be involved in the pathogenesis of various inflammatory diseases. Although macrolide antibiotics display well described immunomodulatory properties, presumably involved in their clinical effects, their impact on inflammasome activation has not been investigated.
Gualdoni GA, Lingscheid T, Schmetterer KG, Hennig A, Steinberger P, Zlabinger GJ.   +5 more
europepmc   +5 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Inflammasome-mediated cell death in response to bacterial pathogens that access the host cell cytosol: lessons from Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2013
Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream ...
Cierra Nichole Casson, Sunny eShin
doaj   +1 more source