Novel perspectives on non-canonical inflammasome activation [PDF]
ImmunoTargets and Therapy, 2015 Catherine Emma Diamond,1,2 Hanif Javanmard Khameneh,1 David Brough,2 Alessandra Mortellaro,1 1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore; 2Faculty of Life Sciences, University of Manchester ...
Diamond CE +3 more
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An overview of the non-canonical inflammasome. [PDF]
Mol Aspects Med, 2020 Inflammasomes are large cytosolic multiprotein complexes assembled in response to infection and cellular stress, and are crucial for the activation of inflammatory caspases and the subsequent processing and release of pro-inflammatory mediators. While caspase-1 is activated within the canonical inflammasome, the related caspase-4 (also known as caspase-
Downs KP +3 more
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Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases. [PDF]
Int J Mol Sci, 2022 An inflammatory response consists of two consecutive steps: priming and triggering, to prepare and activate inflammatory responses, respectively. The cardinal feature of the triggering step is the activation of intracellular protein complexes called inflammasomes, which provide a platform for the activation of inflammatory signaling pathways.
Yi YS.
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Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases. [PDF]
Int J Mol SciInflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which were discovered first and are activated in response to a variety of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and non ...
Yi YS.
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The Role of Non-canonical and Canonical Inflammasomes in Inflammaging [PDF]
Frontiers in Molecular Neuroscience, 2022 Neurodegenerative diseases currently affect millions of people worldwide and continues to increase in the expanding elderly population. Neurodegenerative diseases usually involve cognitive decline and are among the top causes of death.
Brianna Cyr +5 more
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Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways [PDF]
Frontiers in Cell and Developmental Biology, 2020 Inflammasomes, multiprotein complex induced by harmful factors in the body, play a crucial role in innate immunity. Activation of inflammasomes lead to the activation of casepase-1 and then the secretion of inflammatory cytokines, including IL-1β and IL ...
Huiling Xiang +3 more
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Canonical and Non-canonical Inflammasome Activation by Outer Membrane Vesicles Derived From Bordetella pertussis [PDF]
Frontiers in Immunology, 2020 Outer Membrane Vesicles (OMVs) derived from different Gram-negative bacteria have been proposed as an attractive vaccine platform because of their own immunogenic adjuvant properties. Pertussis or whooping cough is a highly contagious vaccine-preventable
Maia L. Elizagaray +7 more
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Microbial sensing through the non-canonical inflammasome modulates airway type 2 immunity [PDF]
Frontiers in ImmunologyIntroductionAirway epithelial cells serve as critical sensors of both microbes and allergens, orchestrating immune responses through damage-associated molecular patterns including IL-33.
Olivier Bernard +8 more
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Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasome [PDF]
Life Science Alliance, 2018 This study provides a detailed molecular mechanism for caspase-11 activation within the non-canonical inflammasome, giving new insight into host defence against cytosolic bacterial infection.
Connie Ross +4 more
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Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles. [PDF]
Cell Rep Med, 2023 The non‐canonical inflammasome sensor caspase‐11 and the pyroptosis executor gasdermin D (GSDMD) are known drivers of inflammation and pyroptosis, a type of regulated immunogenic cell death known to favor cell mediated immunity (CMI) in the context of cancer, infection, and autoimmunity. However, the role of the noncanonical inflammasome components and
Muñoz-Wolf N +16 more
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