Results 21 to 30 of about 4,547,686 (290)

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling [PDF]

Nature, 2015
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock.
Kayagaki, Nobuhiko, Stowe, Irma, Lee, Bettina, O'Rourke, Karen, Anderson, Keith, Warming, Søren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui, Liu, Peter, Lill, Jennie, Li, Hong, Wu, Jiansheng, Kummerfeld, Sarah, Zhang, Juan, Lee, Wyne, Snipas, Scott, Salvesen, Guy, Morris, Lucy, Fitzgerald, Linda, Zhang, Yafei, Bertram, Edward, Goodnow, Christopher, Dixit, Vishva   +24 more
openaire   +4 more sources

Crystal structure of caspase-11 CARD provides insights into caspase-11 activation. [PDF]

Cell Discov, 2020
AbstractMurine caspase-11 is the centerpiece of the non-canonical inflammasome pathway that can respond to intracellular LPS and induce pyroptosis. Caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain.
Liu M, Zhou K, Xu Z, Ma H, Cao X, Yin X, Zeng W, Zahid A, Fu S, Ni K, Ye X, Zhou Y, Bai L, Zhou R, Jin T.   +14 more
europepmc   +4 more sources

Noncanonical inflammasomes: caspase-11 activation and effector mechanisms.

PLoS Pathogens, 2013
Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for caspase-1.
Petr Broz, Denise M Monack
doaj   +6 more sources

Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria

Frontiers in Immunology, 2022
Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Carissa K. Harvest, Edward A. Miao, Edward A. Miao, Edward A. Miao   +6 more
doaj   +1 more source

Caspase-3 western blot. [PDF]

, 2022
Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410), Bernd Schmeck (334625), Hans-Helge Müller (158349), Thorsten Steinfeldt (9870476), Hinnerk Wulf (745052), Kerstin Seidel (385253), Wilhelm Bertrams (3172785), Marc-Alexander Oestreich (13961375)   +7 more
core   +1 more source

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Frontiers in Cellular and Infection Microbiology, 2023
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not ...
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang   +10 more
doaj   +1 more source

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11 [PDF]

Nature, 2021
Mouse caspase-11 and human caspase-4 and caspase-5 recognize cytosolic lipopolysaccharide (LPS) to induce pyroptosis by cleaving the pore-forming protein GSDMD1-5. This non-canonical inflammasome defends against Gram-negative bacteria6,7. Shigella flexneri, which causes bacillary dysentery, lives freely within the host cytosol where these caspases ...
Zilin Li, Wang Liu, Jiaqi Fu, Sen Cheng, Yue Xu, Zhiqiang Wang, Xiaofan Liu, Xuyan Shi, Yaxin Liu, Xiangbing Qi, Xiaoyun Liu, Jingjin Ding, Feng Shao   +12 more
openaire   +2 more sources

Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases

Cells, 2022
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ...
Christophe Paget, Emilie Doz-Deblauwe, Nathalie Winter, Benoit Briard   +3 more
doaj   +1 more source

Caspase-8 contributes to TNF-licensed release of IL-1 family cytokines, but not expression of caspase-11, following L. pneumophila infection. [PDF]

, 2023
Ripk3-/- and Ripk3-/-Casp8-/- BMDMs were primed with either 10 ng/mL rTNF or PBS mock control for 16 hours prior to infection with non-replicating ΔflaA L. pneumophila at MOI = 50. (A) Supernatants were analyzed by ELISA at 24 hpi.
Víctor R. Vázquez Marrero (16033149), Sunny Shin (263038), Tzvi Y. Pollock (16033146), Igor E. Brodsky (11565512)   +3 more
core   +1 more source

Caspase-11: The Noncanonical Guardian of Cytosolic Sanctity [PDF]

Cell Host & Microbe, 2013
Caspase-11 controls a noncanonical inflammasome that responds to Gram-negative bacteria and certain pore-forming toxins. Aachoui et al. (2013) and Case et al. (2013) identify a role for caspase-11 in rapid responses to bacterial pathogens that access the cytosol via vacuolar membrane disruption or the activity of specialized secretion systems.
Shin, Sunny, Brodsky, Igor E.
openaire   +2 more sources