Results 21 to 30 of about 4,545,902 (287)

1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells [PDF]

Frontiers in Pharmacology
Background1-Nitropyrene (1-NP) is harmful to the respiratory system and can evoke acute lung injury (ALI). Pyroptosis and apoptosis, two important types of programmed cell death, are involved in the pathological process of ALI.
Zhao-Lei Ding, Zhao-Lei Ding, Zhao-Lei Ding, Yi-Chen Ma, Chuan-Mei Liu, Chuan-Mei Liu, Xiu Lu, Xiu Lu, Rong-Rong Wang, Rong-Rong Wang, Min-Min Tang, Min-Min Tang, Dong-Xu Hua, Dong-Xu Hua, Ling Zheng, Ling Zheng, Hui Zhao, Hui Zhao, Hui Zhao, Lin Fu, Lin Fu, Lin Fu   +21 more
doaj   +2 more sources

The involvement of caspase-11 in TPEN-induced apoptosis [PDF]

FEBS Letters, 2008
The depletion of intracellular zinc with N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) induces protein synthesis-dependent apoptosis. Here we examined the involvement of caspase induction in apoptosis.
Kim, Yu-Jin, Hana Ra, Koh, Jae-Young, Yang-Hee Kim, Lee, Jong-Min, Kang, Shin-Jung, Han, SeungJin, Shin-Jung Kang, SeungJin Han, Jae-Young Koh, Jong-Min Lee, Yu-Jin Kim, Kim, Yang-Hee, Ra, Hana   +13 more
core   +3 more sources

Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages [PDF]

Frontiers in Immunology, 2023
IntroductionNon-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the population and is a leading cause of cirrhosis and hepatocellular carcinoma.
Charles Drummer, Fatma Saaoud, Nirag C. Jhala, Ramon Cueto, Yu Sun, Keman Xu, Ying Shao, Yifan Lu, Huimin Shen, Ling Yang, Yan Zhou, Jun Yu, Sheng Wu, Nathaniel W. Snyder, Wenhui Hu, Jia ‘Joe’ Zhuo, Yinghui Zhong, Xiaohua Jiang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang   +20 more
doaj   +2 more sources

Revisiting Caspase-11 Function in Host Defense [PDF]

Cell Host & Microbe, 2013
Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence.
Monack, Denise M., Ng, Tessie M.
core   +3 more sources

Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production [PDF]

Frontiers in Immunology
IntroductionKlebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, the mechanisms underlying K.
Yuqi Zhou, Zhuodong Chai, Ankit Pandeya, Ling Yang, Yan Zhang, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei   +8 more
doaj   +2 more sources

Non-canonical inflammasome activation targets caspase-11

Nature, 2011
Caspase-1 activation by inflammasome scaffolds comprised of intracellular nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) and the adaptor ASC is believed to be essential for production of the pro-inflammatory cytokines interleukin ...
Sherry Heldens, Juan Zhang, Dixit, Vishva M, Salina Louie, Vishva M. Dixit, Vande Walle, LieselotteGE350019973966178010018125430009-0001-3953-936722109836-F0EE-11E1-A9DE-61C894A0A6B4, Newton, Kim, Lieselotte Vande Walle, Lamkanfi, MohamedGE350019960063828010015031530000-0002-6350-72691E5D1DC2-F0EE-11E1-A9DE-61C894A0A6B4, Zhang, Juan, Merone Roose-Girma, Kayagaki, Nobuhiko, Vande Walle, Lieselotte, Louie, Salina, Søren Warming, Dong, Jennifer, Jinfeng Liu, Wyne P. Lee, Lee, Wyne P, Roose-Girma, Merone, Jennifer Dong, Qu, Yan, Liu, JinFeng, Yan Qu, Mohamed Lamkanfi, Kim Newton, Nobuhiko Kayagaki, Warming, Soren, Heldens, Sherry, Lamkanfi, Mohamed   +29 more
core   +4 more sources

Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus [PDF]

MedComm
Noncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of pyroptosis in SLE pathogenesis remains unclear ...
Yue Xin, Changxing Gao, Lai Wang, Qianmei Liu, Qianjin Lu   +4 more
doaj   +2 more sources

Caspase-11 signaling enhances graft-versus-host disease [PDF]

Nature Communications, 2019
An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11,
Yanyan Lu, Ran Meng, Xiangyu Wang, Yajing Xu, Yiting Tang, Jianfeng Wu, Qianqian Xue, Songlin Yu, Mingwu Duan, Dongyong Shan, Qingde Wang, Haichao Wang, Timothy R. Billiar, Xianzhong Xiao, Fangping Chen, Ben Lu   +15 more
doaj   +3 more sources

Differential roles of caspase-1 and caspase-11 in infection and inflammation [PDF]

Scientific Reports, 2017
Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis.
Kanneganti, Thirumala-Devi, Briard, Benoit, Rajendra Karki, Amanda Burton, Gingras, Sebastien, Pelletier, Stephane, Si Ming Man, Sebastien Gingras, Stephane Pelletier, Man, Si Ming, Benoit Briard, Thirumala-Devi Kanneganti, Karki, Rajendra, Burton, Amanda   +13 more
core   +4 more sources

Crystal structure of caspase-11 CARD provides insights into caspase-11 activation. [PDF]

Cell Discov, 2020
AbstractMurine caspase-11 is the centerpiece of the non-canonical inflammasome pathway that can respond to intracellular LPS and induce pyroptosis. Caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain.
Liu M, Zhou K, Xu Z, Ma H, Cao X, Yin X, Zeng W, Zahid A, Fu S, Ni K, Ye X, Zhou Y, Bai L, Zhou R, Jin T.   +14 more
europepmc   +4 more sources