Results 101 to 110 of about 1,979 (216)

Nuclear Factor κB Inhibitors Alleviate and the Proteasome Inhibitor PS-341 Exacerbates Radiation Toxicity in Zebrafish Embryos [PDF]

, 2016
Inflammatory changes are a major component of the normal tissue response to ionizing radiation, and increased nuclear factor κB (NF-κB) activity is an important mediator of inflammatory responses. Here, we used zebrafish embryos to assess the capacity of
Daroczi, Borbala, Dicker, Adam, MD, PhD, Kari, Gabor, Ren, Qing, Rodeck, Ulrich   +4 more
core   +1 more source

“Metabolight”: how light spectra shape plant growth, development and metabolism

Physiologia Plantarum, Volume 176, Issue 6, November/December 2024.
Abstract Innovations in light technologies (i.e. Light Emitting Diodes; LED) and cover films with specific optical features (e.g. photo‐selective, light‐extracting) have revolutionized crop production in both protected environments and open fields.
Giulia Lauria, Costanza Ceccanti, Ermes Lo Piccolo, Hafsa El Horri, Lucia Guidi, Tracy Lawson, Marco Landi   +6 more
wiley   +1 more source

Recent Advances in the Biomedical Applications of Copper Nanomaterial‐Mediated Cuproptosis

Advanced NanoBiomed Research, Volume 4, Issue 8, August 2024.
This review summarizes the importance of copper metabolism and balance in the body and proposes that disruption of copper homeostasis can lead to cytotoxicity. Based on it, some copper‐based nanomaterials and compounds are reviewed for their combined application in antitumor and antibacterial fields through cuproptosis combined with other therapeutic ...
Sijia Wu, Qian Wang, Yuhao Li, Baolin Liu, Yuqing Miao   +4 more
wiley   +1 more source

Antiviral Plant Extracts [PDF]

, 2019
Herbal therapy has been an important part of health and wellness for hundreds of years. The renewed interest in medicinal plants has focused on herbal cures among indigenous populations around the world.
Anbazhagan, Ganesh Kumar, Joseph, Baby, Palaniyandi, Sankarganesh   +2 more
core   +2 more sources

Propyl gallate inhibits adipogenesis by stimulating extracellular signal-related kinases pathway in human adipose tissue-derived mesenchymal stem cells [PDF]

, 2013
Biological Sciences ProgramMesencymal stem cells (MSCs) are isolated from various mesenchymal tissues and differentiate into osteoblast, myocyte, and adipocyte.
Lee, Jeung-eun
core  

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors [PDF]

The hepatitis C virus (HCV) NS5B is essential for viral RNA replication and is therefore a prime target for development of HCV replication inhibitors.
Basu, Amartya, Bopda-Waffo, Alain, Costa, Paulo R. R., da Silva, Alcides J. M., Kaushik-Basu, Neerja, Noël, François, Sarafianos, Stefan G., Talele, Tanaji T.   +7 more
core   +2 more sources

S100A4 Drives Non-Small Cell Lung Cancer Invasion, Associates with Poor Prognosis, and is Effectively Targeted by the FDA-Approved Anti-Helminthic Agent Niclosamide [PDF]

, 2016
S100A4 (metastasin-1), a metastasis-associated protein and marker of the epithelial to mesenchymal transition, contributes to several hallmarks of cancer and has been implicated in the progression of several types of cancer.
Arnold, Susanne M., Carpenter, Brittany L., Chen, Min, Durbin, Eric B., Gal, Tamas S., Knifley, Teresa, Liu, Lili, O\u27Connor, Kathleen L., Stewart, Rachel L., Wang, Chi, Weiss, Heidi L., West, Dava S.   +11 more
core   +3 more sources

Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

Phytotherapy Research, Volume 38, Issue 6, Page 3060-3079, June 2024.
Abstract Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects as human estrogens. These compounds do not directly affect biological functions but can act as agonists or antagonists depending on the level of endogenous estrogen in the body.
Vivek P. Chavda, Amit Z. Chaudhari, Pankti C. Balar, Amol Gholap, Lalitkumar K. Vora   +4 more
wiley   +1 more source

Peripheral nerve‐derived Sema3A promotes osteogenic differentiation of mesenchymal stem cells through the Wnt/β‐catenin/Nrp1 positive feedback loop

Journal of Cellular and Molecular Medicine, Volume 28, Issue 8, April 2024.
Abstract Sensory nerves play a crucial role in maintaining bone homeostasis by releasing Semaphorin 3A (Sema3A). However, the specific mechanism of Sema3A in regulation of bone marrow mesenchymal stem cells (BMMSCs) during bone remodelling remains unclear. The tibial denervation model was used and the denervated tibia exhibited significantly lower mass
Jingcun Shi, Bingqing Zhang, Ziqian Wu, Yuhan Zhang, Anand Gupta, Xudong Wang, Jieyu Wang, Lisha Pan, Meng Xiao, Shijian Zhang, Lei Wang   +10 more
wiley   +1 more source

Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells

Journal of Neuroinflammation, 2010
Background Interleukin (IL)-6 plays a pivotal role in a variety of CNS functions such as the induction and modulation of reactive astrogliosis, pathological inflammatory responses and neuroprotection.
Dohi Shuji, Iida Hiroki, Yamaguchi Shinobu, Matsushima-Nishiwaki Rie, Tanabe Kumiko, Kozawa Osamu   +5 more
doaj   +1 more source