Results 161 to 170 of about 1,979 (216)

Insights into Antiviral Candidates against Oropouche Virus: A Molecular Dynamics Study. [PDF]

ACS Phys Chem Au
Colherinhas G, Cardoso WB.
europepmc   +1 more source

Unveiling Molecular Interactions: Coumarin Derivatives and Dengue Virus Protein Targets [PDF]

Cardona Villada, Wilson
core  

A practical total synthesis of wedelolactone

Synthetic Communications, 2023
Wedelolactone, a benzofuran based natural product that can be isolated from Eclipta prostrata, exhibits a variety of biological activities. It is inefficient to obtain wedelolactone from natural sources, so it is of great significance to perform total ...
Hongqian Gou, Jungan Zhang, Peipei Li, Chonglong Li, Hao Wang, Wei Hong   +5 more
semanticscholar   +2 more sources

ROS-Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF-κB-LCN2 Inflammatory Feedback Loop.

Advanced Science, EarlyView.
Intervertebral disc degeneration (IVDD) is driven by persistent inflammation-oxidative stress that disrupts annulus fibrosus (AF) homeostasis. Guided by network pharmacology and docking, we prioritized the NF-κB-LCN2 axis as a druggable target of ...
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
semanticscholar   +2 more sources

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Wedelolactone: A molecule of interests.

Fitoterapia, 2022
The search for bioactive molecules from medicinal plants of the family Asteraceae has been one of the targets in various phytochemical and pharmacological investigations for many years. According to these studies, wedelolactone, a coumestan of the secondary metabolite type, is a key compound found in several Eclipta and Wedelia herbal plants.
Nguyen Manh Ha, Nguyen Quang Hop, N. Son
semanticscholar   +3 more sources

Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs

Organic & Biomolecular Chemistry, 2023
A green approach, catalyzed by the catecholase enzyme obtained from sweet potato, to generate bioactive wedelolactone and many of its analogs which are useful precursors for a variety of coumestan-based natural products.
Anushree Achari, Sourav Chatterjee, Sudip Dey, Tapas K. Kundu, Parasuraman Jaisankar   +4 more
openaire   +2 more sources

Total Synthesis of Wedelolactone

The Journal of Organic Chemistry, 2003
The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium-catalyzed Sonogashira reaction and the palladium-catalyzed carbonylative annulation reaction.
Chuang Chuang, Li, Zhi Xiang, Xie, Yan Dong, Zhang, Jia Hua, Chen, Zhen, Yang   +4 more
openaire   +2 more sources

Wedelolactone induces apoptosis and pyroptosis in retinoblastoma through promoting ROS generation

International Immunopharmacology, 2022
Retinoblastoma is a most frequently occurring primary intraocular tumor in infancy and children, highlighting the requirement to find and develop novel and more effective therapeutic approaches. Wedelolactone (WDL), a nature compound isolated from E.
Hua, Jiang, Chuanqiang, Niu, Yiqun, Guo, Zhenyin, Liu, Yizhou, Jiang   +4 more
openaire   +2 more sources

A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities.

Chinese Journal of Natural Medicines
Plant-derived natural products have long been a vital source for developing therapeutic drugs. Wedelolactone (WDL), a coumestan isolated from Eclipta prostrata, Wedelia calendulacea, Wedelia chinensis, and Sphagneticola trilobata, demonstrates a broad spectrum of therapeutic potential, including anticancer, anti-inflammatory, anti-obesity, anti ...
Haiping Cai, Yue Wu, Xiaojin Zhang
semanticscholar   +3 more sources

Redox state alters anti‐cancer effects of wedelolactone

Environmental and Molecular Mutagenesis, 2012
AbstractWedelolactone is one of the active plant polyphenolic compounds. Anti‐tumor effects of this drug have been demonstrated recently. We have described that wedelolactone acts as catalytic inhibitor of DNA topoisomerase IIα. The aim of this study was to further characterize the mechanism of its anti‐tumor effects.
Petr, Benes, Petra, Alexova, Lucia, Knopfova, Alena, Spanova, Jan, Smarda   +4 more
openaire   +2 more sources