Results 171 to 180 of about 1,979 (216)

Trypsin inhibitory effect of wedelolactone and demethylwedelolactone

Phytotherapy Research, 2003
AbstractWedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC50 values of WL and DWL were found to be 2.9 and 3.0 µg/mL respectively. Copyright © 2003 John Wiley & Sons, Ltd.
Samiulla D, Syed, Mundkinajeddu, Deepak, Shivanna, Yogisha, Arun P, Chandrashekar, Keerthi A, Muddarachappa, Prashanth, D'Souza, Amit, Agarwal, B V, Venkataraman   +7 more
openaire   +2 more sources

Inhibition of topoisomerase IIα: Novel function of wedelolactone

Cancer Letters, 2011
The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFκB transcription factor and/or androgen receptors.
Petr, Benes, Lucia, Knopfova, Filip, Trcka, Alice, Nemajerova, Diana, Pinheiro, Karel, Soucek, Miroslav, Fojta, Jan, Smarda   +7 more
openaire   +2 more sources

Synthetic analogues of wedelolactone

Tetrahedron, 1961
Abstract The syntheses of 7′-methoxy- and 5′,7′,6-trimethoxy-coumarino(3′,4′:3,2)coumarones (IIa and IIb) are described.
T.R. Govindachari, K. Nagarajan, P.C. Parthasarathy   +2 more
openaire   +1 more source

Die Synthese des Wedelolactons

Chemische Berichte, 1963
AbstractBei der Dehydrierung von Brenzcatechin in Gegenwart von 45‐Dihydroxy‐;7‐methoxy‐cumarin entsteht mit guter Ausbeute Wedelolacton.
Hans‐Werner Wanzlick, Reinhard Gritzky, Hans Heidepriem   +2 more
openaire   +1 more source

[Wedelolactone alleviates hyperoxia-induced acute lung injury by regulating ferroptosis].

Zhonghua wei zhong bing ji jiu yi xue, 2023
To study whether wedelolactone can reduce hyperoxia-induced acute lung injury (HALI) by regulating ferroptosis, and provide a basic theoretical basis for the drug treatment of HALI.A total of 24 C57BL/6J mice were randomly divided into normal oxygen control group, HALI model group and wedelolactone pretreatment group, with 8 mice in each group. Mice in
Junya Liu, Song Qin, Banghai Feng, Miao Chen, Hong-xun Mei   +4 more
semanticscholar   +3 more sources

Standardization of Karisalai Madakku Tailam and Quantification of Wedelolactone by HPTLC

Pharmacognosy Research
Murugammal Shanmugam, Subhasri Rajasekar, Priyanka Sekaran, Hemavathy Rajasekaran, Shakila Ramachandran   +4 more
semanticscholar   +2 more sources

A new and efficient synthesis of wedelolactone derivatives

Chinese Journal of Chemistry, 2004
AbstractA new and facile method based on an intermolecular cycloaddition was described for the synthesis of wedelolactone derivatives.
Deng‐Huang Gong, Ling Zhang, Jin‐Feng Li, Jun‐Ying Yuan, Cheng‐Ye Yuan   +4 more
openaire   +1 more source

Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.

Journal of Ethnopharmacology
INTRODUCTION Sepsis-induced liver injury (SILI) is a severe complication of sepsis. Wedelolactone (WEL) can be used to treat liver diseases. However, its therapeutic mechanisms and efficacy in SILI remain unclear.
Yanping Yin, Fei Mu, Lulu Zhang, Jinyi Zhao, Rui Gong, Yanli Yin, Lingling Zheng, Yang Du, Fuxing Jin, Jingwen Wang   +9 more
semanticscholar   +1 more source

Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity

Drug Development and Industrial Pharmacy, 2011
Wedelolactone is isolated from the dried leaves of Eclipta alba (L.) and reported to be effective as a potential hepatoprotective, antibacterial and anti hemorrhagic. Pharmacokinetic studies of wedelolactone reveal its poor absorption through the intestine.
Kirti, Upadhyay, Nishant Kumar, Gupta, Vinod Kumar, Dixit   +2 more
openaire   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi-Omics Approach to Unravel the Mechanism.

Advancement of science
Neutropenia, a common complication in cancer patients undergoing radiotherapy, heightens the risk of infection and mortality, with limited treatment options.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Lin-Wei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
semanticscholar   +1 more source