Results 181 to 190 of about 1,979 (216)

Wedelolactone mitigates mitochondrial dysfunction to enhance food-related biochemical interventions in disc degeneration

Italian Journal of Food Science
Intervertebral disc degeneration (IVDD), a prevalent age-related musculoskeletal disorder, poses a significant global health burden. While understanding that its pathogenesis and identifying its effective therapeutic compounds remain essential ...
Min Zhang, Bin Hu, Liangye Sun
semanticscholar   +1 more source

Wedelolactone inhibits osteoclastogenesis but enhances osteoblastogenesis through altering different semaphorins production

International Immunopharmacology, 2018
Our previous study showed that wedelolactone, isolated from Ecliptae herba, enhanced osteoblastogenesis but inhibited osteoclastogenesis through Sema3A signaling pathway. This study aims to investigate the role of other semaphorins in wedelolactone-enhanced osteoblastogenesis and -inhibited osteoclastogenesis.
Xue, Deng, Li-Na, Liang, Di, Zhu, Lu-Ping, Zheng, Jing-Hua, Yu, Xiang-Ling, Meng, Yi-Ning, Zhao, Xiao-Xin, Sun, Tao-Wen, Pan, Yan-Qiu, Liu   +9 more
openaire   +2 more sources

Estimation of Wedelolactone in Eclipta alba and Wedelia chinensis and Comparative Antimicrobial Activity against Pathogenic Bacteria

Universities' Journal of Phytochemistry and Ayurvedic Heights
Eclipta alba (L.) Hassk. and Wedelia chinensis (Osbeck) Merr., both belonging to the Asteraceae family, are well known in traditional medicine. Wedelo-lactone, a coumestan derivative, is considered a key bioactive constituent due to its potent anti ...
Z. Mehmood, S. Chhimwal, A. K. Dixit
semanticscholar   +1 more source

Wedelolactone, a component from Eclipta prostrata (L.) L., inhibits the proliferation and migration of head and neck squamous cancer cells through the AhR pathway.

Current Pharmaceutical Biotechnology, 2022
BACKGROUND Ecliptae prostrata (L.) L. has been widely used in east Asia with reported biological activities including anti-cancer properties. OBJECTIVE We aimed to investigate the effect of ethyl acetate extract of Ecliptae prostrata (L.) L.
Yingxiang Zou, Zhen-qiang Mu, Jie Wang, S. Tian, Yilin Li, Yanqiu Liu   +5 more
semanticscholar   +1 more source

Wedelolactone inhibits ferroptosis and alleviates hyperoxia-induced acute lung injury via the Nrf2/HO-1 signaling pathway.

Toxicological Sciences
Hyperoxia-induced acute lung injury (HALI) is a complication of oxygen therapy. Ferroptosis is a vital factor in HALI. This paper was anticipated to investigate the underlying mechanism of Wedelolactone (WED) on ferroptosis in HALI.
Kang Li, Xiaoqin Wang, Zhenliang Liao, Junya Liu, Banghai Feng, Yingcong Ren, Ni-Nan Dai, Kun Yu, Hong Yu, Huajun Chen, Hong-xun Mei, Song Qin   +11 more
semanticscholar   +1 more source

Wedelolactone suppresses breast cancer growth and metastasis via regulating TGF-β1/Smad signaling pathway.

The Journal of pharmacy and pharmacology
OBJECTIVE Breast cancer is a malignant tumor with high invasion and metastasis. TGF-β1-induced epithelial-mesenchymal transition (EMT) is crucially involved in the growth and metastasis of breast cancer.
Hui Li, Manting Hou, Ping Zhang, Lutong Ren, Yuanyuan Guo, Liang Zou, Junling Cao, Zhaofang Bai   +7 more
semanticscholar   +1 more source

Wedelolactone Attenuates Liver Fibrosis and Hepatic Stellate Cell Activation by Suppressing the Hippo Pathway

Rejuvenation Research
Liver fibrosis is a commonly observed pathological phenomenon that occurs during the progression of various types of chronic liver diseases. The Hippo pathway is closely associated with the pathogenesis of liver fibrosis. Previous studies have shown that
Wei Zhang, Kai Gao, Ya Bai, Dong Xu, Meina Zhao, Xing Tao, Jingwen Wang   +6 more
semanticscholar   +1 more source

Hepatoprotective Effect of Wedelolactone against Concanavalin A-Induced Liver Injury in Mice

The American Journal of Chinese Medicine, 2018
Eclipta prostrata L. is a traditional Chinese herbal medicine that has been used in the treatment of liver diseases. However, its biological mechanisms remain elusive. The current study aimed to investigate the hepatoprotective effect of wedelolactone, a major coumarin ingredient of Eclipta prostrata L., on immune-mediated liver injury.
Qingqiong, Luo, Jieying, Ding, Liping, Zhu, Fuxiang, Chen, Lili, Xu   +4 more
openaire   +2 more sources

Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis

International Immunopharmacology, 2019
Wedelolactone, a chemical compound extracted from Wedelia calendulacea or Eclipta alba, has been reported to regulate key steps in inflammation. However, the effects of wedelolactone on fungal keratitis are not known. Hence, we aimed to characterize the impact of wedelolactone in Aspergillus fumigatus keratitis.Aspergillus fumigatus was used to ...
Min, Cheng, Jing, Lin, Cui, Li, Wenyi, Zhao, Hua, Yang, Leyu, Lv, Chengye, Che   +6 more
openaire   +2 more sources

Comprehensive Analysis of NADH:Ubiquinone Oxidoreductase Subunit B3 in Gynecological Tumors and Identification of Its Natural Inhibitor Wedelolactone

Chemical Biology and Drug Design
The aim of this study was to explore the role of NADH:ubiquinone oxidoreductase subunit B3 (NDUFB3) in human gynecological malignancies and to screen potential natural compounds targeting it.
Huiping Li, Yangli Jin, Yanyan Zhang, Xiaohua Xie, Nan Li   +4 more
semanticscholar   +1 more source