Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus [PDF]
MedCommNoncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of pyroptosis in SLE pathogenesis remains unclear ...
Yue Xin +4 more
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Pyroptosis and polarization of macrophages in septic acute lung injury induced by lipopolysaccharide in mice [PDF]
Immunity, Inflammation and DiseaseBackground Pyroptosis and polarization are significant contributors to the onset and development of many diseases. At present, the relationship between pyroptosis and polarization in acute lung injury (ALI) caused by sepsis remains unclear.
Sijiang Zhou +3 more
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Wedelolactone enhances osteoblastogenesis but inhibits osteoclastogenesis through Sema3A/NRP1/PlexinA1 pathway [PDF]
Frontiers in Pharmacology, 2016 Bone remodeling balance is maintained by tight coupling of osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Thus, agents with the capacity to regulate osteoblastogenesis and osteoclastogenesis have been investigated for therapy
Yanqiu Liu +3 more
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Wedelolactone Ameliorates Ischemic Stroke by Inhibiting Oxidative Damage and Ferroptosis via HIF-1α/SLC7A11/GPX4 Signaling. [PDF]
Drug Des Devel TherPurpose Wedelolactone (Wel), a furocoumarin compound extracted from the medicinal plant Eclipta prostrata L. has been shown to exhibit significant neuroprotective effects.
Tao X +10 more
europepmc +2 more sources
Molecular mechanism of wedelolactone inhibits high glucose-induced human retinal vascular endothelial cells injury through regulating miR-190 expression. [PDF]
Medicine (Baltimore)To investigate the effects and molecular mechanisms of wedelolactone (WEL) on high glucose-induced injury of human retinal vascular endothelial cells (HRECs).
Cai X, Wang X, Huang Y, Rao X.
europepmc +2 more sources
Wedelolactone from Eclipta prostrata (L) L. suppresses inflammation and improves insulin resistance
Asian Pacific Journal of Tropical BiomedicineObjective: To evaluate the effects of wedelolactone, a major flavonoid from Vietnamese Eclipta prostrata (L) L., on inflammation and insulin resistance. Methods: Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata (L.) L.
Trinh Tat Cuong +5 more
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Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway [PDF]
Frontiers in Pharmacology, 2019 Pulmonary fibrosis is common in a variety of inflammatory lung diseases, there is currently no effective clinical drug treatment. It has been reported that the ethanol extract of Eclipta prostrata L.
Jin-yu Yang +6 more
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Antioxidant Effects of E. alba: A Narrative Review
Journal of Pharmacy and Bioallied SciencesEclipta alba Linn, commonly known as Bhringaraja, exhibits significant antioxidant activity as demonstrated in various studies. Research has shown that E.
Keyur Dudhat +3 more
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CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis [PDF]
International Journal of OphthalmologyAIM: To explore whether CD3ε is involved in the adaptive immunity of Aspergillus fumigatus (A. fumigatus) keratitis in mice and the role of innate and adaptive immunity in it. METHODS: Mice models of A.
Wen-Hao Shi +6 more
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Wedelolactone: A Natural Anti-inflammatory Coumarin Derivative
International Journal For Multidisciplinary ResearchMedicinal herbs have been extensively studied and utilized for centuries in many developing countries as an effective approach to treat various diseases and health conditions. Wedelolactone (WDL), a key bioactive compound found in Eclipta prostrata (also
Kajal Annasaheb Bondre +1 more
semanticscholar +2 more sources