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Effect of Wedelolactone on CCl4 Induced Liver Damage
Indian Journal of Applied Research, 2011The hepatoprotective activity of ethanolic extract and wedelolactone isolated from EcliptaalbaL. (Family: Asteraceae) was studied against CCl induced, acute hepatotoxicity in rats. 4 Hepatoprotective activity was studied by estimating biochemical analysis of blood viz.
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TẠP CHÍ KHOA HỌC TRƯỜNG ĐẠI HỌC QUỐC TẾ HỒNG BÀNG
Đặt vấn đề: Nhóm hợp chất flavonoid trong dược liệu cỏ mực (Eclipta prostrata L.) có hoạt tính kháng khuẩn, kháng nấm, cầm máu, giải độc gan,… Có nhiều phương pháp định lượng hợp chất flavonoid toàn phần ở Việt Nam và trên thế giới, riêng dược liệu cỏ ...
Cát Huy Khôi Cát Huy Khôi +1 more
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Đặt vấn đề: Nhóm hợp chất flavonoid trong dược liệu cỏ mực (Eclipta prostrata L.) có hoạt tính kháng khuẩn, kháng nấm, cầm máu, giải độc gan,… Có nhiều phương pháp định lượng hợp chất flavonoid toàn phần ở Việt Nam và trên thế giới, riêng dược liệu cỏ ...
Cát Huy Khôi Cát Huy Khôi +1 more
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Protective effect of wedelolactone against CCl 4 -induced acute liver injury in mice
International Immunopharmacology, 2016Eclipta, a traditional Chinese medicine, has been used to treat liver disease for centuries. However, the chemical basis and biological mechanisms of Eclipta remain elusive. The current study aims to investigate the hepatoprotective effect of wedelolactone (WEL), a major coumarin in Eclipta, using C57BL/6 mice with carbon tetrachloride CCl4-induced ...
Yang Lu +8 more
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Anti-Inflammatory Gallic Acid and Wedelolactone Are G Protein-Coupled Receptor-35 Agonists
Pharmacology, 2012G protein-coupled receptor-35 (GPR35) has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Gallic acid and caffeic acids are reported to modulate allergic reactions via unknown mode(s) of action. Here we attempt to elucidate whether both phenolic acids share a common mode of action with the two asthma drugs.
Huayun, Deng, Ye, Fang
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Materials Science and Engineering: C, 2019
In this study, an antitumor drug delivery system, gold nanoshell coated wedelolactone liposomes (AuNS-Wed-Lip), were designed and synthesized. In the drug delivery system, wedelolactone liposome and gold-nanoshell were linked by l-cysteine, which had been shown an effective nanocarrier for antitumor drug delivery, on-demand drug release, and ...
Xuwu, Zhang +8 more
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In this study, an antitumor drug delivery system, gold nanoshell coated wedelolactone liposomes (AuNS-Wed-Lip), were designed and synthesized. In the drug delivery system, wedelolactone liposome and gold-nanoshell were linked by l-cysteine, which had been shown an effective nanocarrier for antitumor drug delivery, on-demand drug release, and ...
Xuwu, Zhang +8 more
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Wedelolactone induces growth of breast cancer cells by stimulation of estrogen receptor signalling
The Journal of Steroid Biochemistry and Molecular Biology, 2015Wedelolactone, a plant coumestan, was shown to act as anti-cancer agent for breast and prostate carcinomas in vitro and in vivo targeting multiple cellular proteins including androgen receptors, 5-lipoxygenase and topoisomerase IIα. It is cytotoxic to breast, prostate, pituitary and myeloma cancer cell lines in vitro at μM concentrations. In this study,
Tereza, Nehybova +4 more
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On-demand drug release of ICG-liposomal wedelolactone combined photothermal therapy for tumor
Nanomedicine: Nanotechnology, Biology and Medicine, 2016In the study, a new photoresponsive nano drug delivery system was developed by encapsulating indocyanine green into liposomes (ICG-liposomal wedelolactone), which could improve the water solubility and bioavailability of wedelolactone. The hyperthermia, produced by ICG under near-infrared (NIR) light irradiation, promoted wedelolactone release rapidly ...
Xuwu, Zhang +7 more
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An Improved Total Synthesis of Wedelolactone
SSRN Electronic Journal, 2022Hongqian Gou +5 more
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Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2
European Journal of Pharmacology, 2013Wedelolactone is a major coumarin of Eclipta prostrata, which is used for preventing liver damage. However the effects of wedelolactone on hepatic fibrosis remained unexplored. The purpose of this study was to demonstrate the anti-fibrotic effects of wedelolactone on activated human hepatic stellate cell (HSC) line LX-2 and the possible underlying ...
Yanzhe, Xia +6 more
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Wedelolactone: Unveiling the Multifaceted Anti-inflammatory Potential.
PharmacologyWedelolactone (WED) is a polyphenolic compound with a coumarin skeleton isolated from marigold. Despite its wide application in traditional medicine, its mechanisms of action and safety profile require further investigation. The innovation of this review
Lu Zhang +7 more
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