Results 21 to 30 of about 1,979 (216)

Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma [PDF]

Respiratory Research
Background The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation.
Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng   +13 more
doaj   +2 more sources

The search for an antiviral lead molecule to combat the neglected emerging Oropouche virus [PDF]

Current Research in Microbial Sciences
Oropouche virus (OROV) is a member of the Peribunyaviridae family and the causative agent of a dengue-like febrile illness transmitted by mosquitoes. Although mild symptoms generally occur, complications such as encephalitis and meningitis may develop. A
Rafaela dos Santos Peinado, Marielena Vogel Saivish, Gabriela de Lima Menezes, Umberto Laino Fulco, Roosevelt Alves da Silva, Karolina Korostov, Raphael Josef Eberle, Paulo A. Melo, Maurício Lacerda Nogueira, Carolina Colombelli Pacca, Raghuvir Krishnaswamy Arni, Mônika Aparecida Coronado   +11 more
doaj   +2 more sources

Discovery of wedelolactone from Eclipta Prostrata (L.) Linn. as a natural PDE4 inhibitor with potent anti-psoriasis effects

Acta Materia Medica
Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability to regulate inflammatory signaling pathways.
Lingyu Wu, Yingying Wu, Shangding Yang, Siyu Jin, Qing Zhang, Zhongbin Cheng, Chaohui Wu, Yiming Hao, Ling Sun, Wenwen Liu, Donglei Shi, Jian Li, Yi-You Huang, Baoli Li, Hai-Bin Luo   +14 more
doaj   +2 more sources

Wedelolactone Mitigates Alcoholic Steatohepatitis via Modulating the TLR4/MyD88/NF-κB Pathway

Mediators of Inflammation
Background. Wedelolactone (WEL) has demonstrated anti-inflammatory properties. However, the therapeutic effect and underlying mechanisms of WEL against alcoholic steatohepatitis (ASH) remain unclear.
Tao Jiang, Bingde Hu, Yongxia Li, Shuihong Yu   +3 more
doaj   +2 more sources

Wedelolactone attenuates angiotensin II-stimulated hypertrophy in H9C2 cardiomyocytes

Signa Vitae
Cardiomyocyte hypertrophy is the adaptive response of the heart to various physiological or pathological stresses. To combat this type of disease, more effective drugs are still needed.
Rufeng Zhang, Linlin Jiang, Du Xiong, Chang Bian, Jingjing He   +4 more
semanticscholar   +2 more sources

Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non-alcoholic fatty liver disease. [PDF]

J Pharm Anal, 2023
Chen P, Zhu Z, Geng H, Cui X, Han Y, Wang L, Zhang Y, Lu H, Wang X, Zhang Y, Sun C.   +10 more
europepmc   +2 more sources

The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition [PDF]

Acta Pharmaceutica Sinica B
The pathogenesis of pulmonary fibrosis (PF) is complex. It is characterized by myofibroblast hyperplasia and deposition of collagen protein. Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in lung fibroblasts and epithelial cells, but its functions in ...
Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, Ting Zhu, Louqian Zhang, Chaofeng Zhang   +6 more
doaj   +2 more sources

Palladium(II)-Catalyzed Efficient Synthesis of Wedelolactone and Evaluation as Potential Tyrosinase Inhibitor [PDF]

Molecules, 2019
Tyrosinase is an enzyme widely distributed in nature, which has multiple functions, especially in the melanin biosynthesis pathway. Despite the few clinically available tyrosinase inhibitors for whitening, a great demand remains for novel compounds with ...
Huidan Huang, Jianqiu Chen, Jie Ren, Chaofeng Zhang, Fei Ji   +4 more
doaj   +3 more sources

Screening the Active Phytochemicals From <i>Eclipta prostrata</i> and Unraveling Their Molecular Insight Into Human Malignancies. [PDF]

Cancer Innov
This review comprehensively analyses the phytochemicals from Eclipta prostrata, identifying 25 active compounds with chemotherapeutic potential against 15 different human malignancies. These compounds modulate diverse and complex mechanisms, including targeting critical signaling pathways (e.g., PI3K/AKT/mTOR), inducing regulated cell death (e.g., FAS,
Hossain MS, Khatun S, Mia MM, Zohora F, Sarker MR, Tanjida Islam KM, Sayeed MA, Mou MA, Hamidu S, Hamidu F, Wasaf Hasan AM, Mumtaj S, Hossain MK, Sohel M.   +13 more
europepmc   +2 more sources

TGFBI Inhibits the Pyroptosis of Macrophages to Ameliorate Septic Shock. [PDF]

J Cell Mol Med
ABSTRACT Septic shock is one of the leading causes of morbidity and mortality in hospital patients. The present study aimed to investigate the potential of transforming growth factor β induced (TGFBI) in macrophage functions and progression of septic shock.
Zou S, Li L, Lv B.
europepmc   +2 more sources