Results 31 to 40 of about 1,979 (216)
Journal of Ayurveda and Integrative Medicine, 2023 Background: Wedelolactone, main active constituent of Wedelia calendulace and Eclipta alba plants which has been traditionally used to treat various chronic inflammatory conditions.
T. Prakash, Suresh Janadri
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Wedelolactone Promotes the Chondrogenic Differentiation of Mesenchymal Stem Cells by Suppressing EZH2. [PDF]
Int J Stem Cells, 2023 Osteoarthritis (OA) is a degenerative disease that leads to the progressive destruction of articular cartilage. Current clinical therapeutic strategies are moderately effective at relieving OA-associated pain but cannot induce chondrocyte differentiation or achieve cartilage regeneration.
Qin W +6 more
europepmc +3 more sources
ACS Central Science, 2023 Soluble epoxide hydrolase (sEH) plays a critical role in inflammation by modulating levels of epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs).
Juan Zhang +8 more
semanticscholar +1 more source
Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARα/LPL and LDLR. [PDF]
PLoS ONE, 2015 Hyperlipidemia is considered one of the greatest risk factors of cardiovascular diseases. We investigated the anti-hyperlipidemic effect and the underlying mechanism of wedelolactone, a plant-derived coumestan, in HepG2 cells and high-fat diet (HFD ...
Yun Zhao +6 more
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Folia Histochemica et Cytobiologica, 2022 INTRODUCTION: Rheumatoid arthritis (RA) is an autoimmune disorder associated with joint damage and attendant cardiovascular complications. Wedelolactone (Wed), derived from Eclipta alba, possesses anti-inflammatory activity.
Jingjing Cao +3 more
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Biomolecules, 2021 Eclipta prostrata (L.) L. (Syn.: Eclipta alba (L.) Hassak, Family: Asteraceae) is an important medicinal plant in the tropical and subtropical regions. It is widely used in treating various diseases of skin, liver and stomach in India, Nepal, Bangladesh,
Deepak Timalsina, Hari Prasad Devkota
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Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells [PDF]
International Journal of Molecular Sciences, 2017 Wedelolactone is a multi-target natural plant coumestan exhibiting cytotoxicity towards cancer cells. Although several molecular targets of wedelolactone have been recognized, the molecular mechanism of its cytotoxicity has not yet been elucidated. In this study, we show that wedelolactone acts as an inhibitor of chymotrypsin-like, trypsin-like, and ...
Tereza Nehybová +8 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 Hepatic fibrosis represents an important event in the progression of chronic liver injury to cirrhosis, and is characterized by excessive extracellular matrix proteins aggregation.
Yongqiang Ai +18 more
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The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]
, 2007 CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris +6 more
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Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action [PDF]
, 2023 This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action.
Chupakhin, Oleg N. +5 more
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