A novel role for thrombopoietin in regulating osteoclast development in humans and mice [PDF]
, 2015 Emerging data suggest that megakaryocytes (MKs) play a significant role in skeletal homeostasis. Indeed, osteosclerosis observed in several MK-related disorders may be a result of increased numbers of MKs.
Barnes, Calvin L. T. +8 more
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Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma [PDF]
Anticancer Research, 2019 Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), possesses histone N-methyltransferase (HMT) activity and plays an essential role in cancer initiation and development. The aim of the present study was to investigate the potential of Wedelolactone (WL) to inhibit the methylation activity of EZH2.The ...
Nadezhda, Romanchikova +1 more
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Current Management Strategies in Breast Cancer by Targeting Key Altered Molecular Players [PDF]
, 2016 Breast Cancer is second largest disease affecting women worldwide. It remains the most frequently reported and leading cause of death among women in both developed and developing countries.
Ashraf Ali +10 more
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Induction of Polyploidy and Metabolic Profiling in the Medicinal Herb Wedelia chinensis
Plants, 2021 Wedelia chinensis, which belongs to the Asteraceae family, is a procumbent, perennial herb. It has medicinal anti-inflammatory properties and has been traditionally used as folk medicine in East and South Asia for treating fever, cough and phlegm.
Yung-Ting Tsai, Po-Yen Chen, Kin-Ying To
doaj +1 more source
Progress in Research on Regulated Cell Death in Cerebral Ischaemic Injury After Cardiac Arrest. [PDF]
J Cell Mol MedABSTRACT Ischaemic damage to the brain is the main cause of brain injury after cardiac arrest. The current treatment focuses on early reperfusion, but reperfusion tends to cause reperfusion injury, which is a significant problem. Cell death is an irreversible and normal end to cell life, playing key roles in maintaining the homeostasis and development ...
Chen Z +5 more
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Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells [PDF]
, 2011 Background Peripheral-type benzodiazepine receptor (PBR) expression levels are low in normal human brain, but their levels increase in inflammation, brain injury, neurodegenerative states and gliomas.
Iida, Hiroki +2 more
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Estudios farmacognósticos de Eclipta prostrate (Linn.) cultivada en Sri Lanka [PDF]
, 2023 Eclipta prostrata Linn. is an annual herbaceous plant used in traditional medicine, commonly known as “Trailing Eclipta” or False Daisy in English, ‘----------Keekirindiya’ in Sinhala and ‘Kayyantakara’ in Tamil.
Arawwawala, Liyanage Dona Ashanthi Menuka +4 more
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Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro
Pharmaceuticals, 2023 Drugs that cure COVID-19 have been marketed; however, this disease continues to ravage the world without becoming extinct, and thus, drug discoveries are still relevant.
Jie Chen +3 more
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Traditional Chinese Medicine Therapy for Targeting Osteoblastogenesis [PDF]
, 2018 Osteoblasts are derived from bone marrow mesenchymal stem cell (BMSC) precursors, which differentiate into mature osteoblasts and mediate bone formation. This process is called osteoblastogenesis. A deficiency in osteoblastogenesis of BMSCs can result in
Liu, Yanqiu
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Drug Design, Development and Therapy, 2021 Sadia Sarwar,1,2 Abir A Alamro,3 Amani A Alghamdi,3 Komal Naeem,4 Salamat Ullah,5 Muazzam Arif,6 Jun Qing Yu,1 Fazlul Huq7 1Discipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus, Sydney, NSW, Australia ...
Sarwar S +7 more
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