Results 61 to 70 of about 1,979 (216)
Frontiers in Bioengineering and Biotechnology, 2019 Wedelolactone (WED) is commonly used for the treatment of doxorubicin (DOX)-induced kidney damage, but its efficacy is limited by its poor solubility and bioavailability.
Liang Feng +12 more
doaj +1 more source
Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-kappa B pathways [PDF]
, 2012 Minimally modified low density lipoprotein (mmLDL) is a well-known risk factor for coronary artery disease. Upregulation of vascular endothelin type B (ETB) receptors on the vascular smooth muscle cells is predicted to be the molecular mechanism that ...
Cao, Yong-Xiao +4 more
core +1 more source
Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling
International Journal of Oncology, 2014 The bone is the most common metastatic site of breast cancer. Bone metastasis causes pain, pathologic fractures, and severely reduces the quality of life. Breast cancer causes osteolytic bone metastasis, which is dependent on osteoclast-mediated bone resorption.
Chia-Jung, Hsieh +8 more
openaire +3 more sources
Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways
Frontiers in Public Health, 2020 Anaplasma phagocytophilum subverts neutrophil function permitting intracellular survival, propagation and transmission. Sustained pro-inflammatory response, recruitment of new host cells for population expansion, and delayed apoptosis are associated with
J. Stephen Dumler +5 more
doaj +1 more source
Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response [PDF]
, 2015 We recently demonstrated that the secreted aspartyl proteinases (Saps), Sap2 and Sap6, of Candida albicans have the potential to induce the canonical activation of NLRP3-inflammasome leading to the secretion of IL-1β and IL-18 via caspase-1 activation ...
Gabrielli E +8 more
core +1 more source
KINETICS OF ULTRASOUND ASSISTED EXTRACTION OF WEDELOLACTONE FROM Eclipta alba [PDF]
Brazilian Journal of Chemical Engineering, 2016 Abstract Ultrasound assisted extraction of wedelolactone, a major coumestan present in Eclipta alba, is investigated in the present work.Various process parameters such as type of solvent, power, solvent to solid ratio and extraction temperature, which affect the extraction yield, are optimized.
Charpe, T. W., Rathod, V. K.
openaire +3 more sources
Memorias do Instituto Oswaldo Cruz, 1991 Small molecular weight compounds from Mandevilla velutina and from Eclipta prostata were found to be active against snakebite.
Walter B. Mors
doaj +1 more source
Biomedicines, 2022 N-methyl-N-nitrosourea (NMU) is widely used to model oxidative stress and inflammation mediated retinal neurodegeneration. Wedelolactone (WD) is known to have antioxidant, anti-inflammatory, and neuroprotective roles.
Kevin Harkin +4 more
doaj +1 more source
Phytochemical Screening of Methanolic Extract and Antibacterial Activity of Active Principles of Hepatoprotective Herb, Eclipta alba [PDF]
, 2010 Aerial parts of Eclipta alba are used traditionally for the treatment of several diseases of liver, skin and stomach. Methanolic extract and active principle compound of a well known Indian hepatoprotective herb, Eclipta alba was tested for in vitro ...
Dalal, Sunita +3 more
core +2 more sources
Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions
MedComm, Volume 7, Issue 2, February 2026.Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian +8 more
wiley +1 more source