Results 41 to 50 of about 31,818 (279)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Compressible flow structures interaction with a two-dimensional ejector: a cold-flow study [PDF]

open access: yes, 2009
An experimental study has been conducted to examine the interaction of compressible flow structures such as shocks and vortices with a two-dimensional ejector geometry using a shock-tube facility. Three diaphragm pressure ratios ofP4 =P1 = 4, 8, and 12
Ben-Dor G.   +14 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Scaling limits of integrable quantum field theories [PDF]

open access: yes, 2011
Short distance scaling limits of a class of integrable models on two-dimensional Minkowski space are considered in the algebraic framework of quantum field theory.
Babujian H. M.   +10 more
core   +3 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Modelling the response of building material specimens during fracture tests [PDF]

open access: yes, 2012
Práce se zabývá výpočtovým modelováním wedge splitting testu betonového vzorku pomocí numerické metody konečných prvků. Jsou řešeny různé úrovně výpočtového modelu pro různou hloubku zářezu a umístění vazeb.
Navrátil, Petr
core  

A Technique for Making Nuclear Fusion in Solids [PDF]

open access: yes, 2017
A technique is described for making nuclear fusion at room temperature by compressing a powder mixture comprising a deuteride and catalytic material. The result is explosive beyond known chemical reaction for the materials.
WAYTE, RICHARD
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Wedge splitting test of wood for fracture parameters estimation of Norway Spruce

open access: yesEngineering Fracture Mechanics, 2020
Abstract Crack evolution in wood from Norway Spruce during mode I wedge splitting tests was measured using a Digital Image Correlation (DIC) system. The resulting series of deformation fields were post-processed in order to obtain kinematically based crack tip location histories throughout the loading procedure, by a purposely made algorithm.
Katarzyna Ostapska, Kjell Arne Malo
openaire   +1 more source

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