Results 111 to 120 of about 88,180 (332)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo   +5 more
wiley   +1 more source

A statistical exploration of interval-deficient wind speed data for application to wind power assessments

open access: yesJournal of Energy in Southern Africa, 2019
Gathering quality wind speed data can be time-consuming and expensive. The present study established whether interval-deficient wind speed data could be rendered useful for wind power assessments.
F. Lubbe, T. Harms, J. Maritz
doaj   +1 more source

Weibull distribution based on maximum likelihood with interval inspection data [PDF]

open access: yes
The two Weibull parameters based upon the method of maximum likelihood are determined. The test data used were failures observed at inspection intervals.
Rheinfurth, M. H.
core   +1 more source

An objective Bayesian method for including parameter uncertainty in ensemble model output statistics

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Conventional model output statistics and ensemble model output statistics methods for calibrating ensemble forecasts lead to severe underestimation of the probabilities of ensemble extremes (in blue). This is because they ignore statistical parameter uncertainty.
Stephen Jewson   +4 more
wiley   +1 more source

ESTIMASI PARAMETER DISTRIBUSI WEIBULL DUA PARAMETER MENGGUNAKAN METODE BAYES

open access: yesMEDIA STATISTIKA, 2012
Interval estimation of a parameter is one part of statistical inference. One of the methods that used is the Bayes method. A Bayesian method is combine prior distribution and distribution of samples, so that the posterior distribution can be obtained. Interval estimation using a method Bayes called credibel interval estimation.
Indria Tsani Hazhiah   +2 more
openaire   +2 more sources

Mechanistic Insight Into Ionizable Cationic Lipid‐Mediated Endosomal Escape via Transient Lipid Complexes

open access: yesSmall, EarlyView.
Coarse‐grained simulations show that the formation of transient anionic–cationic lipid pairs regulates the rate‐limiting step for the lamellar‐to‐hexagonal phase transition in mixtures of anionic and cationic lipids mimicking the endosomal membrane after fusion with lipid‐based nanoparticles, thus playing an important role in the endosomal escape of ...
David Noel Zimmer   +2 more
wiley   +1 more source

Lumpy Labor Adjustment as a Propagation Mechanism of Business Cycles [PDF]

open access: yes
I explore the aggregate effects of micro lumpy labor adjustment in a prototypical RBC model, which embeds a stochastic labor duration mechanism in the spirit of Calvo(1983), and it extends this approach by introducing a Weibull-distributed labor ...
Fang Yao
core  

Microstructure, Defects, and Fatigue Response of High‐Strength Tool Steels

open access: yessteel research international, EarlyView.
The martensitic tool steel family is designed for use in various working environments where they are subjected to repeatedly high mechanical loads. Despite the continuous upgrade of material´s microstructures through compositional development or processing techniques, defects remain a critical factor for the tool performance by leading to fatigue ...
Katerina Chantziara   +3 more
wiley   +1 more source

On the derivation of an analytical expression for wind power probability distribution function and capacity factor of turbine

open access: yesInternational Journal of Sustainable Energy
It is shown here that if the PDF (Probability Distribution Function) of wind speed is a Rayleigh distribution with parameter [Formula: see text], then the PDF of wind power is a Weibull distribution with parameters [Formula: see text], where [Formula ...
Emin Gardashov, Rauf Gardashov
doaj   +1 more source

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