Results 101 to 110 of about 68,815 (223)

Proteomic Signatures of Ectopic Fat Distribution: Tissue‐Specific Drivers and Clinical Implications

Med Research, EarlyView.
Integration of plasma proteomics and multi‐organ MRI in 666 UK Biobank participants, combined with a knockoff‐based causal inference and machine learning framework, reveals organ‐specific drivers of ectopic fat: PLA2G1B (pancreas), ERBB2/IGFBP2 (liver), CA14 (muscle), and NCAM2/TNFRSF10B (pericardium). These drivers engage distinct pathways (e.g., PI3K‐
Bing Zhang, Fen Yang, Xingji Lian, Jie He, Shuijin Huang, Mingjuan Fan, Yin Liang, Jiaqiang Huang, LongYan Yin, Hong Wang   +9 more
wiley   +1 more source

Reachable Workspace as a Clinical Outcome for Upper Extremity Function: A Narrative Review

Muscle &Nerve, EarlyView.
ABSTRACT Motion sensing technology can be utilized to capture detailed upper extremity (UE) motion to reconstruct an individual's three‐dimensional (3D) reachable workspace (RWS). The RWS can be quantified as relative surface area (RSA), providing an innovative surrogate measure to assess UE mobility and function.
Jay J. Han, Lawrence J. Hayward, Christina Adams, Juan Perez‐Ibarra   +3 more
wiley   +1 more source

Association Between Weight-Adjusted Waist Circumference Index and Metabolic Disease-Associated Fatty Liver Disease: A Retrospective Study

Risk Management and Healthcare Policy
Ting Tang,1,* Hua Fan,2,* Qingwen Yu,1 Xiyun Rao,1 Yongmin Shi,1 Xuhan Tong,1 Lanlan Feng,1 Zhao Xu,1 Xinyan Fu,1 Juan Chen,1 Xingwei Zhang,1 Jiake Tang,1 Hu Wang,1 Mingwei Wang1,3– 6 1Department of Cardiology, the Affiliated Hospital of ...
Tang T, Fan H, Yu Q, Rao X, Shi Y, Tong X, Feng L, Xu Z, Fu X, Chen J, Zhang X, Tang J, Wang H, Wang M   +13 more
doaj  

Association between Weight-Adjusted Waist Index and Depression in NAFLD: the modulating roles of sex and BMI

BMC Psychiatry
Abstract Background The Weight-Adjusted Waist Index (WWI) is a novel indicator of obesity that accurately reflects body composition. However, the association between WWI and depression in patients with non-alcoholic fatty liver disease (NAFLD) remains unclear.
Jingwen Zhang, Yan Wang, Sunkui Ke, Tianyu Xie, Lijun Liu, Xiaoyu Fu, Chenhao Wang, Xiao Huang   +7 more
openaire   +3 more sources

Impact of a low‐carbohydrate diet on cardiometabolic parameters in individuals with and without diabetes: An 8‐year longitudinal study within the ELSA‐Brasil cohort

Nutrition in Clinical Practice, EarlyView.
Abstract Background Low‐carbohydrate diets (LCDs) are widely adopted for metabolic management, but their long‐term cardiometabolic effects in diverse populations remain unclear. We aimed to evaluate the association between self‐selected moderate LCD adherence and cardiometabolic parameters in individuals with and without diabetes.
Leticia Batista de Azevedo, Haysla Xavier Martins, Oscar Geovanny Enriquez‐Martinez, Maria del Carmen Bisi Molina   +3 more
wiley   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Association Between Weight-Adjusted Waist Index and Depressive Symptoms in Older Adults

Hitit Medical Journal
Objective: Depression is a common and disabling condition in older adults. Identifying simple, non-invasive predictors of depression risk is essential for early intervention. The Weight-Adjusted Waist Index (WWI), a novel anthropometric marker of central adiposity, may be associated with depressive symptoms in older populations.
Ayşe Dikmeer, Suna Bürkük
openaire   +1 more source

Trends in Diagnosing Obesity: The CALOR Study

Obesity, EarlyView.
Data from the CALOR study suggest that in people with elevated BMI in the US and Japan, there is underdiagnosis of obesity and a high prevalence of diseases interrelated to obesity. ABSTRACT Objective This study aimed to describe characteristics of people with elevated BMI by presence versus absence of obesity diagnosis and trends over time.
Deborah B. Horn, Eva Lesén, Christen M. Gray, Magnus Bjursell, Hironori Waki   +4 more
wiley   +1 more source

Time‐Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study

Obesity, EarlyView.
ABSTRACT Objective Time‐restricted eating (TRE) has gained attention for weight loss and cardiometabolic health improvement. The Time‐Restricted Intake of Meals (TRIM) study was a 12‐week randomized isocaloric and eucaloric feeding trial comparing 10‐h TRE to a 16‐h usual eating pattern (UEP) in adults with obesity and either prediabetes or diet ...
Daisy Duan, Susan Carnell, Scott J. Pilla, Stephanie T. Chung, Jeanne M. Clark, Nisa M. Maruthur   +5 more
wiley   +1 more source

Early Pregnancy Body Roundness Index and Development of Adverse Pregnancy Outcomes: A Secondary Analysis of the nuMoM2b Study

Obesity, EarlyView.
Greater body roundness index is associated with increased odds of adverse pregnancy outcomes. Thomas et al. Relationships between body roundness with body fat and visceral adipose tissue emerging from a new geometrical model. Obesity (Silver Spring). 2013 November; 21(11): 2264–2271. Central image created with BioRender.
Kelsey J. Pape, Taylor M. Bynarowicz, Sruthi Bhamidipalli, Yan Tong, Maisa N. Feghali, David M. Haas, Uma M. Reddy, Robert M. Silver, Lynn M. Yee, Christina M. Scifres   +9 more
wiley   +1 more source