Results 81 to 90 of about 122,077 (293)

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad   +4 more
wiley   +1 more source

BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants [PDF]

open access: yes, 2016
 To conduct a systematic review and meta-analysis of cohort studies of body mass index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the dose-response curve, and the influence on the results of confounding from ...
Aune, D   +7 more
core   +2 more sources

Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review

open access: yesChronic Diseases and Translational Medicine, EarlyView.
Frailty phenotypes and risk of cardiovascular disease. Sarcopenic obese phenotype is associated with increased prevalence of cardiovascular risk factors and progression of metabolic syndrome, leading to cardiovascular events and cardiovascular mortality, while the Anorexic malnourished phenotype is associated with reduced prevalence of cardiovascular ...
Ishleen Oberoi   +5 more
wiley   +1 more source

Weight-adjusted waist index as a new predictor of osteoporosis in postmenopausal patients with T2DM. [PDF]

open access: yesSci Rep
This study aimed to investigate the predictive value of the weight-adjusted waist index (WWI) for osteoporosis in postmenopausal patients with type 2 diabetes mellitus (T2DM). This cross-sectional study included 229 postmenopausal patients with T2DM (mean age 64.53 ± 7.4 years). Collect anthropometric data.
Du G   +10 more
europepmc   +4 more sources

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

open access: yes, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas   +72 more
core   +1 more source

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

open access: yesChronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves   +8 more
wiley   +1 more source

Socio-economic determinants of anthropometric measures of abdominal adiposity among older people in England [PDF]

open access: yes, 2012
Objective: to look into the socio-economic determinants of levels of three anthropometric measures of abdominal adiposity among older people in England -body mass index, waist circumference (WC), and waist-hip ratio (WHR)- and of changes along two health
Jose Iparraguirre, Sam SzeLam
core   +1 more source

Resilience Practices and Post‐Traumatic Growth Among Sudanese IDPs

open access: yesConflict Resolution Quarterly, EarlyView.
ABSTRACT In this paper we examine the resilience of internally displaced persons (IDPs) in Sudan who have endured various forms of suffering resulting from being targeted or trapped by militants involved in large‐scale violence. Upon escaping the conflict zones, the civilians exhibit strength, adaptability, and wisdom in the face of various threats to ...
Karina Korostelina   +2 more
wiley   +1 more source

Pre-pregnancy predictors of hypertension in pregnancy among Aboriginal and Torres Strait Islander women in north Queensland, Australia; a prospective cohort study [PDF]

open access: yes, 2013
BACKGROUND Compared to other Australian women, Indigenous women are frequently at greater risk for hypertensive disorders of pregnancy. We examined pre-pregnancy factors that may predict hypertension in pregnancy in a cohort of Aboriginal and Torres ...
Adrian Esterman   +36 more
core   +2 more sources

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