Results 51 to 60 of about 2,912,633 (312)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Weight-Bearing Estimation for Cane Users by Using Onboard Sensors

Sensors, 2019
Mobility is a fundamental requirement for a healthy, active lifestyle. Gait analysis is widely acknowledged as a clinically useful tool for identifying problems with mobility, as identifying abnormalities within the gait profile is essential to correct ...
Joaquin Ballesteros, Alberto Tudela, Juan Rafael Caro-Romero, Cristina Urdiales   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Three-Dimensional Bone Alignment from Cone-Beam Computed-Tomography Scans in Weight-Bearing and Clinical Outcomes Following the Modified Grice–Green Surgical Procedure for Adult Acquired Flatfoot

Applied Sciences
Severe adult-acquired flatfoot deformity is widely addressed surgically via the Grice–Green subtalar arthrodesis. Standard radiographic measurements have been reported, but these are limited to planar views.
Giulio Sacchetti, Claudio Belvedere, Maurizio Ortolani, Alberto Leardini, Luigi Piarulli, Marco Miceli, Daniela Platano, Lisa Berti   +7 more
doaj   +1 more source

PERFORMANCE, PATIENT BENEFITS AND ACCEPTANCE OF A NEW GENERATION OF MICROPROCESSOR-CONTROLLED STANCE AND SWING CONTROL ORTHOSIS

Canadian Prosthetics & Orthotics Journal, 2018
INTRODUCTION By enabling users to flex the orthotic leg during swing phase and safely lock it during stance phase, stance control orthosis (SCO) offers clear benefits compared to locked knee-ankle-foot-orthosis (KAFO)1.
Nadine Wismer, OA Alexander Krebs, Frank Braatz, Thomas Schmalz, Andreas Kranzl, Christian Breuer   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Analysis of medial deviation of center of pressure after initial heel contact in forefoot varus

Journal of the Formosan Medical Association, 2016
After initial heel contact, the rearfoot everts and causes medial deviation of the center of pressure (CoP). Although rearfoot angle in single-limb stance has been associated with forefoot varus (FV) ≥ 8°, medial CoP deviation has not.
Wei-Li Hsi
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

AAFD : conventional radiographs are not enough! I need the third dimension

, 2019
There is an increasing amount of literature suggesting that 3-dimensional (3D) weight-bearing computed tomography (WBCT) imaging overcomes the inherent limits of traditional bidimensional imaging in foot and ankle surgery.
Alessio Bernasconi, Alexej Barg, Bernasconi, Alessio, Burssens A, Arne Burssens, François Lintz, Lintz F., de Cesar Netto, Cesar, Weight Bearing CT International Study Group, Richter, Martinus, Burssens, Arne, Barg, Alexej, de Cesar Netto C, Martinus Richter, Bernasconi A, Barg A, Richter A, Cesar de Cesar Netto, Lintz, François   +18 more
core   +1 more source