Results 71 to 80 of about 2,912,633 (312)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Reverse total shoulder replacement for patients with "weight-bearing" shoulders [PDF]

open access: yes
Reverse total shoulder arthroplasty (rTSA) has gained popularity in recent years and is indicated for a wide variety of shoulder pathologies. However, use of rTSA in patients with "weight-bearing" shoulders that support wheelchair use or crutches has ...
Tsvieli, Oren   +4 more
core  

Effects of Repeated Exposure to Ambient Cold on the Development of Inflammatory Pain in a Rat Model of Knee Arthritis

open access: yesLife
This study investigated the effects of ambient cold exposure on inflammatory pain development, synovial cytokine levels, and spinal cord glial cell activation. Male Sprague–Dawley rats (6 weeks old) were divided into Cold and RT groups.
So-Hee Kim   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Walangkura Napanangka, Kintore, Northern Territory, 2007 [picture] /

open access: yes, 2007
Title devised by cataloguer based on inscriptions.; Part of the collection: Portraits of prominent indigenous artists of the Western Desert region of the Northern Territory, 2007.; Inscriptions: "A/P GW"--In ink below image; Photographer's blind stamp ...
Weight, Greg, 1946-
core  

Assessment of forearm and plantar foot load in the elderly using a four-wheeled walker with armrest and the effect of armrest height

open access: yesClinical Interventions in Aging, 2014
Chang-Yong Ko,* Sol-Bi Kim,* Hyuk-Jae Choi, Yunhee Chang, Sungjae Kang, Yoon Heo, Jeicheong Ryu, Gyoosuk Kim, Museong Mun Korea Orthopedics and Rehabilitation Research Center, Incheon, South Korea *These authors contributed equally to this work ...
Ko CY   +8 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Long Jack Phillipus Tjakamarra, Northern Territory, 2007 [picture] /

open access: yes, 2007
Title devised by cataloguer based on inscriptions.; Part of the collection: Portraits of prominent indigenous artists of the Western Desert region of the Northern Territory, 2007.; Inscriptions: Photographer's blind stamp lower right corner; "A/P Long ...
Weight, Greg, 1946-
core  

WEIGHT-BEARING COMPUTED TOMOGRAPHY OF THE FOOT AND ANKLE: AN UPDATE AND FUTURE DIRECTIONS.

open access: yes, 2023
Spatial understanding of osteoarticular deformities of the foot and ankle is vital to correct diagnosis and therapeutic decision making. Poor reproducibility in conventional standing radiography in three orthogonal views has driven the development of ...
Godoy-Santos, Alexandre Leme   +2 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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