MP704REGIONAL DIFFERENCES IN THE ASSOCIATIONS BETWEEN PRESCRIBED DIALYSATE SODIUM CONCENTRATION AND INTERDIALYTIC WEIGHT GAIN IN THE DIALYSIS OUTCOMES AND PRACTICE PATTERNS STUDY: A CALL FOR QUALITY ASSURANCE? [PDF]
, 2017 Manfred Hecking +4 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Tenofovir alafenamide fumarate use for HIV pre-exposure prophylaxis and weight gain. [PDF]
Sci RepShi F, Xia H, Weissman S, Li X, Yang X.
europepmc +1 more source
Effects of pre-pregnancy BMI and gestational weight gain on pregnancy and neonatal outcomes in Poland [PDF]
Justyna Marchewka +6 more
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
A Meta-Analysis Examining the Impact of Levothyroxine Supplementation on Gestational Weight Gain in Women with Overt Hypothyroidism. [PDF]
Iran J Nurs Midwifery ResMohammadi R +3 more
europepmc +1 more source
Sleep timing and longitudinal weight gain in 4‐ and 5‐year‐old children
, 2014 Rebecca J. Scharf, Mark D. DeBoer
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source